ArticleJournal of oral and maxillofacial pathology : JOMFP
Assessment of miR-760 expression as a potential diagnostic biomarker in oral squamous cell carcinoma: A RT-PCR study.
Article in Journal of oral and maxillofacial pathology : JOMFP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Oral squamous cell carcinoma (OSCC) is an important global health burden and is often diagnosed at an advanced stage. MicroRNAs (miRNAs) are evolving as key regulators of cancer development and progression, with potential roles as diagnostic and prognostic biomarkers. Among them, microRNA-760 (miR-760) has shown tumour-suppressive activity in several cancers; however, its role in oral squamous cell carcinoma remains unclear. Objective: The objective of this study was to evaluate the expression pattern of miRNA-760 in tissues of oral squamous cell carcinoma compared to normal oral mucosa using quantitative real-time polymerase chain reaction (qRT-PCR), and to assess its potential clinical utility as a diagnostic biomarker. Methods: Thirty histologically confirmed oral squamous cell carcinoma tissue samples and 20 healthy oral mucosal tissue samples were analysed. Total ribonucleic acid was extracted from formalin-fixed paraffin-embedded sections, converted to complementary deoxyribonucleic acid (cDNA), and subjected to (qRT-PCR). Small nuclear RNA U6 was used as the internal reference gene. Delta cycle (ΔCt) threshold values were calculated, and relative expression of miR-760 was determined using the method described as 'two to the power of negative delta cycle threshold (2^-ΔΔCt)'. The Mann-Whitney Results: The expression of miR-760 was significantly higher in oral squamous cell carcinoma tissues. The mean (ΔCt) threshold value for the OSCC group was 1.93 ± 4.04, compared to -1.56 ± 5.11 in the healthy control group ( Conclusion: The up-regulation of miR-760 was found in OSCC tissues. This proves that the distinct expression pattern highlights its potential role as a biomarker for early detection. Further studies are needed to explore its biological role and clinical relevance in oral cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.