Evidence map›Paper›PMID 42064092›Full record

ArticleFrontiers in immunology2026

Dual role of Ninjurin-1 in myeloid cell adhesion and inflammation in relapse-remitting EAE.

Coleen Thompson, Alex Annett, Anastasia Alkhimovitch, Kashish Singh Parihar, Igal Ifergan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Coleen ThompsonDepartment of Molecular and Cellular Biosciences, College of Medicine, University of Cincinnati, Cincinnati, OH, United States.
Alex AnnettDepartment of Molecular and Cellular Biosciences, College of Medicine, University of Cincinnati, Cincinnati, OH, United States.
Anastasia AlkhimovitchDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Kashish Singh PariharDepartment of Molecular and Cellular Biosciences, College of Medicine, University of Cincinnati, Cincinnati, OH, United States.
Igal IferganDepartment of Molecular and Cellular Biosciences, College of Medicine, University of Cincinnati, Cincinnati, OH, United States.

Funding

Role of the neurovascular molecule Wnt in regulating CNS inflammatory responsesR35GM146890 · NIGMS · UNIVERSITY OF CINCINNATI · PI Igal Ifergan · 2022 to 2026
$2.2M
Role of NK cell subsets in an animal model of relapsing-remittingmultiple sclerosisR03NS144870 · NINDS · UNIVERSITY OF CINCINNATI · PI Igal Ifergan · 2025 to 2026
$162k
NIGMS NIH HHS R35 GM146890NINDS NIH HHS R03 NS144870
6 · The paper itself

Abstract

Nerve Injury-Induced Protein 1 (Ninjurin-1) is an adhesion molecule implicated in inflammation and tissue injury, yet its role in neuroinflammatory diseases such as multiple sclerosis (MS) remains poorly defined. Here, we identify Ninjurin-1 as a marker and regulator of immune activation and CNS infiltration in relapsing-remitting experimental autoimmune encephalomyelitis (RR-EAE), a model of relapsing-remitting MS (RRMS). Using flow cytometry, gene-expression profiling, and

Indexed as

Cell Adhesion Molecules, NeuronalEncephalomyelitis, Autoimmune, ExperimentalMultiple Sclerosis, Relapsing-RemittingMyeloid CellsNerve Growth FactorsAnimalsCell AdhesionFemaleHumansInflammationMiceMice, Inbred C57BLCell Adhesion Molecules, NeuronalNerve Growth FactorsNinj1 protein, mouseCNS inflammationEAEmultiple sclerosismyeloid cellsNinjurin-1

Identifiers

PMID42064092
PMCPMC13124630

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.