ArticleFrontiers in immunology2026
Serum anti-β2 spectrin IgA antibodies are produced in a CD4 T cell-independent manner in IgA nephropathy model mouse.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: IgA nephropathy (IgAN) is characterized by deposition of IgA antibodies (Abs) in the glomerular mesangium. In IgAN, the mechanism by which IgA Abs are selectively deposited in the glomerular mesangial region remain unclear. Current study reported the presence of autoantibodies-IgA against β2 spectrin of mesangial cells in sera of IgAN model mice (gddY) and patients with IgAN, and identified β2-spectrin as the target antigen. And it found that IgA Methods: Lymphocytes from kidneys, renal lymph node, spleen, bone marrow and nasopharyngeal associated lymphoid tissue of 3-week-old ddY mice were analyzed by flow cytometry. To deplete CD4 Results: Depletion of CD4 Discussion: Our data suggest that the serum anti-β2-spectrin IgA Abs are produced in a CD4
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