Evidence map›Paper›PMID 42064070›Full record

ArticleFrontiers in immunology2026

Mouse TAPBPR shows functional similarity to human TAPBPR in shaping the MHC-I immunopeptidome.

Juliana Bernardi Aggio, Marcel Wacker, William Guo, Arwen F Altenburg, Ida Hafstrand, Reem Satti, Alison McDowall, Aure Aflalo, Andreas Neerincx, Jack Welland and 6 more

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In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Juliana Bernardi AggioDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.
Marcel WackerDepartment of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany.
William GuoDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.
Arwen F AltenburgDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.
Ida HafstrandDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.
Reem SattiDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.
Alison McDowallDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.
Aure AflaloDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.
Andreas NeerincxDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.
Jack WellandCambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Alice Abreu TorresDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.
Mikkel-Ole SkjoedtRigshospitalet-University Hospital Copenhagen, Copenhagen, Denmark.
Karsten SkjødtUniversity of Southern Denmark, Odense, Denmark.
Jens BauerDepartment of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany.
Juliane S WalzDepartment of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany.
Louise H BoyleDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human TAPBPR is known to function as a Major Histocompatibility Complex class I (MHC-I) peptide exchange catalyst that shapes the peptide repertoire presented to immune cells. However, investigations characterizing TAPBPR from other species are limited. Here, we characterize mouse TAPBPR, exploring its association partners in mouse cell lines and comparing its function to human TAPBPR. We find that mouse TAPBPR binds MHC-I and calnexin, with a notably sustained interaction with H2-D

Indexed as

Histocompatibility Antigens Class IMembrane ProteinsPeptidesAnimalsAntigen PresentationCalnexinCell LineH-2 AntigensHumansMiceProtein BindingCalnexinH-2 AntigensHistocompatibility Antigens Class IMembrane ProteinsPeptidescalnexinH2-DbH2-KbimmunopeptidomeMHC-Imouse TAPBPRpeptide exchange

Identifiers

PMID42064070
PMCPMC13124576

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.