ArticleFrontiers in immunology2026
Integrative single-cell RNA-seq and ATAC-seq analysis reveals the key role of inflammatory cell activation in pulmonary arterial hypertension.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Mechanisms of inflammatory cell activation in periodontitis-induced bone destruction and advances in targeted interventions.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The cellular heterogeneity and molecular complexity of pulmonary arterial hypertension (PAH) have not been fully elucidated. Methods: Here, we constructed an integrative transcriptome and chromatin accessibility atlas of PAH mice by using single-cell RNA sequencing and single-cell ATAC sequencing. Results: In PAH mice, the numbers of granulocytes and monocytes/macrophages in the lung tissues were increased, and the hypoxia-inducing factor pathway was specifically activated in these inflammatory cells. Furthermore, monocyte/macrophage subcluster analysis revealed an increase of chemokine C-C-motif receptor 2 (CCR2) Conclusion: In conclusion, this study established a comprehensive transcriptome and chromatin accessibility atlas for PAH mice and further indicated that activation of S100a9-expressing inflammatory cell might be associated with the development of PAH. Further researches are warranted to investigate the underlying mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.