Evidence map›Paper›PMID 42064053›Full record

ArticleFrontiers in immunology2026

Combination of albumin-lymphocyte score and skeletal muscle index predicts prognosis of patients with ovarian cancer after primary debulking surgery.

Yihong Chen, Quanmin Kang, Dan Nie, Peng Zhang, Xiaoxia Zhou, Zhaoci Li, Yulan Hu, Tan Xin, Han Gong

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Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Yihong Chen *Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Quanmin Kang *Key Laboratory of Reproductive Genetics of National Ministry of Education, Women's Reproductive Health Laboratory of Zhejiang Province, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Dan Nie *Department of Gynecology, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Peng ZhangDepartment of Gynecology and Obstetrics, People's Hospital of Leshan, Leshan, Sichuan, China.
Xiaoxia ZhouDepartment of Gynecology, Panzhihua Central Hospital, Panzhihua, Sichuan, China.
Zhaoci LiDepartment of Gynecology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Yulan HuDepartment of Obstetrics and Gynecology, Wan'an Maternal & Child Health Care Hospital, Wan'an, Jiangxi, China.
Tan XinKey Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Han GongKey Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Accumulating evidence underscores the significance of inflammation and nutrition in tumor progression. Although low albumin-lymphocyte score (ALS) and skeletal muscle index (SMI) are known to be associated with negative outcomes in patients with ovarian cancer (OC) undergoing primary debulking surgery, the usefulness for predicting prognosis remains unclear. We aimed to assess the relevant preoperative prognostic variables and their combined impact on patients with OC. Methods: This retrospective study included 347 patients with primary OC from multiple medical centers. The patients were divided into discovery (237 patients) and validation (110 patients) cohorts. Serological tests and plain computed tomography were performed to quantify the ALS and SMI. We investigated the preoperative prognostic ability of a unique index based on a combination of ALS and SMI, the CAS grade. Results: Patients with a lower ALS and a higher SMI showed improved overall survival (OS) and recurrence-free survival (RFS). Upon stratification by CAS grade, grade 1 patients demonstrated the highest body mass index and the most favorable survival prognosis, whereas grade 3 patients demonstrated the poorest OS and RFS. The independent variables for OS and RFS included residual disease and elevated CAS grade. These findings were validated in an independent cohort study. Conclusion: The CAS grade, a combination of ALS and SMI, is a meaningful and independent predictor of prognosis in patients with OC.

Indexed as

Cytoreduction Surgical ProceduresLymphocytesMuscle, SkeletalOvarian NeoplasmsAdultAgedFemaleHumansMiddle AgedPrognosisRetrospective Studiesalbumin-lymphocyte scoredebulking surgeryovarian cancerprognosisskeletal muscle index

Identifiers

PMID42064053
PMCPMC13125017

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