Evidence map›Paper›PMID 42064049›Full record

ArticleFrontiers in immunology2026

Extracellular caspase-1: a critical inducer and a therapeutic target of lung injury in gut ischemia-reperfusion.

Kouhei Ishikawa, Gaifeng Ma, Alok Jha, Atsushi Murao, Ping Wang, Monowar Aziz

Abstract read
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In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kouhei IshikawaCenter for Immunology and Inflammation, The Feinstein Institutes for Medical Research, Manhasset, NY, United States.
Gaifeng MaCenter for Immunology and Inflammation, The Feinstein Institutes for Medical Research, Manhasset, NY, United States.
Alok JhaCenter for Immunology and Inflammation, The Feinstein Institutes for Medical Research, Manhasset, NY, United States.
Atsushi MuraoCenter for Immunology and Inflammation, The Feinstein Institutes for Medical Research, Manhasset, NY, United States.
Ping Wang *Center for Immunology and Inflammation, The Feinstein Institutes for Medical Research, Manhasset, NY, United States.
Monowar Aziz *Center for Immunology and Inflammation, The Feinstein Institutes for Medical Research, Manhasset, NY, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Caspase-1 is known to function intracellularly. However, whether caspase-1 can be released extracellularly and if so, the mechanisms of its release and action remain unknown. Here, we identify that cleaved caspase-1 (p20), which we named extracellular caspase-1 (eCasp-1), is released from immune cells in association with gasdermin D (GSDMD) pores formation. We identified significantly elevated eCasp-1 levels in the blood of critically ill surgical ICU patients, and in the blood and peritoneal fluid of gut ischemia-reperfusion (I/R) injury mice.

Indexed as

Caspase 1Reperfusion InjuryAnimalsApoptosis Regulatory ProteinsDisease Models, AnimalGasderminsHumansIntracellular Signaling Peptides and ProteinsMacrophagesMaleMiceMice, Inbred C57BLPhosphate-Binding ProteinsSignal TransductionToll-Like Receptor 4Apoptosis Regulatory ProteinsCaspase 1GasderminsGSDMD protein, humanGsdmd protein, mouseIntracellular Signaling Peptides and ProteinsPhosphate-Binding ProteinsToll-Like Receptor 4ALIDAMPsextracellular caspase-1GSDMDgut I/RTLR4

Identifiers

PMID42064049
PMCPMC13124943

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.