Evidence map›Paper›PMID 42064000›Full record

ArticleBJR artificial intelligence2025

Diagnostic accuracy of artificial intelligence-assisted radiology assessment of cancer: a systematic review.

Dylan Zhao, Thomas Packer, Xiaobo Jie, Muhammad Shahid, Jason Oke, Annette Plüddemann

Abstract read
In one paragraph

Article in BJR artificial intelligence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dylan ZhaoUniversity of Oxford Medical Science Division, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom.ORCID https://orcid.org/0009-0005-2612-1112
Thomas PackerUniversity of Oxford Medical Science Division, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom.
Xiaobo JieUniversity of Oxford Medical Science Division, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom.
Muhammad ShahidUniversity of Oxford Medical Science Division, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom.
Jason OkeAbbott Diabetes Care Ltd, Witney, OX29 0YL, United Kingdom.
Annette PlüddemannNuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, Oxford, OX2 6GG, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Perform a systematic review and meta-analysis of studies using multi-reader multi-case (MRMC) study designs for cancer diagnosis with artificial intelligence (AI). Review diagnostic accuracy, study design and reporting. Methods: A search of several databases between January 1, 2014 and February 28, 2024 was performed. Diagnostic accuracy studies that compared radiologists with and without AI-assistance in cancer diagnostic tasks over all imaging modalities were included. Meta-analysis using Summary Receiver Operating Characteristics (SROC) curves were plotted for pooled sensitivity and specificity. Risk of bias was assessed by using the Quality Assessment of Diagnostic Accuracy Studies-Comparative (QUADAS-C) and the Checklist for Artificial intelligence in Medical Imaging (CLAIM). Results: Thirty-four studies were included of which 23 were included in meta-analysis. Eight identified cancers on Chest X-rays, 17 on CT, 9 on MRI. Pooled sensitivity and specificity were 0.67 (95%CI 0.58-0.74) and 0.82 (95%CI 0.75-0.88), respectively, for clinicians and 0.79 (95%CI 0.71-0.88) and 0.87 (95%CI 0.82-0.91) for AI-assistance. 17 of 34 studies (50%) had concern of bias with QUADAS-C. CLAIM assessment highlighted reporting issues in several domains of methodology in a proportion of studies. Conclusion: Artificial intelligence assistance tools may benefit clinician diagnostic performance in cancer diagnosis. Updated reporting guidelines may help to overcome potential methodological limitations to clarify AI's value in healthcare. Advances in knowledge: Previous reviews compare AI accuracy alone against a clinician. We focus on MRMC study designs to ass AI use in a clinical environment.

Indexed as

artificial intelligencecancerdiagnostic accuracymulti-reader mutlicase

Identifiers

PMID42064000
PMCPMC13045702

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.