Evidence map›Paper›PMID 42063992›Full record

ArticleBJR artificial intelligence2025

Artificial intelligence assisted detection of large vessel occlusion on CT angiography in acute stroke patients: a multi-reader multi-case study.

Kiruba Nagaratnam, Phil Mathieson, Anna Podlasek, Peter Slade, Gary A Ford, Anthony Cox, James H Briggs, Zoe V J Woodhead, George Harston

Abstract read
In one paragraph

Article in BJR artificial intelligence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kiruba NagaratnamRoyal Berkshire NHS Foundation Trust, Reading, RG1 5AN, United Kingdom.ORCID https://orcid.org/0000-0003-1455-2773
Phil MathiesonOxford University Hospitals NHS Trust, Stroke Medicine, Oxford, OX3 9DU, United Kingdom.
Anna PodlasekDivision of Radiological and Imaging Sciences, University of Nottingham, Nottingham, NG7 2UH, United Kingdom.ORCID https://orcid.org/0000-0001-7297-7169
Peter SladeStroke Medicine Morriston, Morriston Hospital, Swansea, SA6 6NL, United Kingdom.
Gary A FordOxford University Hospitals NHS Trust, Stroke Medicine, Oxford, OX3 9DU, United Kingdom.
Anthony CoxNorth Bristol NHS Trust, BS10 5NB, United Kingdom.
James H BriggsRoyal Berkshire NHS Foundation Trust, Reading, RG1 5AN, United Kingdom.ORCID https://orcid.org/0009-0000-5211-8770
Zoe V J WoodheadBrainomix Limited, Oxford, OX2 7HN, United Kingdom.ORCID https://orcid.org/0000-0003-0462-6791
George HarstonOxford University Hospitals NHS Trust, Stroke Medicine, Oxford, OX3 9DU, United Kingdom.ORCID https://orcid.org/0000-0003-4916-5757

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: We assessed the impact of artificial intelligence (AI) software (e-CTA, Brainomix) on clinical decision-making in patients with suspected acute ischemic stroke. Methods: A retrospective, multi-reader-multi-case crossover design compared readers' performance with vs without software support. Twenty cases were included, 10 with large vessel occlusion (LVO) and 10 without LVO. Twenty-one NHS clinicians, representing intended software users ranging in experience, conducted 2 sessions (washout period > 2 weeks). In session 1, software support was provided for 10 randomly selected cases. In session 2, support allocation was reversed. Outcome measures included LVO detection, collateral scoring, diagnosis, treatment decision, time taken and confidence. Results: Sensitivity, specificity, and accuracy of LVO detection improved with imaging software for LVO detection, with increased confidence and reduced time taken. There was no significant difference in collateral scoring or diagnoses. Conclusion: e-CTA can improve performance of NHS clinicians when interpreting acute stroke imaging. Advances in knowledge: This paper provides new evidence that AI decision support software has the capacity to improve the performance of representative users in the NHS when interpreting imaging to identify patients for acute stroke treatments.

Indexed as

acute ischemic strokeAIartificial intelligencecollateral scoreCTACT angiographylarge vessel occlusionLVO

Identifiers

PMID42063992
PMCPMC13045686

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.