Evidence map›Paper›PMID 42063926›Full record

ArticleJournal of medical ultrasound

Carotid Blood Flow Assessment during Dynamic Respiratory Maneuvers Demonstrates a Shift toward Vasoconstriction with Increasing Age.

Osian Llwyd, Anna Corby, Klaus Bond, Stephen Payne, Alastair Webb

Abstract read
In one paragraph

Article in Journal of medical ultrasound. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Osian LlwydDepartment of Clinical Neurosciences, Wolfson Centre for Prevention of Stroke and Dementia, University of Oxford, Oxford, UK.
Anna CorbyJackie Walton Vascular Studies Unit, John Radcliffe Hospital, Oxford, UK.
Klaus BondJackie Walton Vascular Studies Unit, John Radcliffe Hospital, Oxford, UK.
Stephen PayneCerebral Haemodynamics Group, Institute of Applied Mechanics and Department of Mathematics, National Taiwan University, Taipei, Taiwan.
Alastair WebbDepartment of Brain Sciences, Imperial College London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Internal carotid artery (ICA) blood flow may be an alternative target to measure cerebrovascular reactivity (CVR) and endothelium-dependent vasodilatory dysfunction. We investigated the feasibility of testing CVR in the ICA during routine clinical carotid investigation. Methods: CVR was assessed by effects of breath-hold (BH) and rapid-breathing (RB) on ICA diameter, blood velocities (peak systolic velocity [PSV], end diastolic velocity [EDV], and mean velocity [MV]), volume flow, and relative to changes in end-tidal carbon dioxide (end-tidal CO Results: In 50 patients (68 ± 13 years old, 15 female), recordings during rest, BH, and RB were of good quality in 96%, 90%, and 88%, respectively. Age-related reductions in blood velocities were evident during rest (EDV: Conclusion: During routine carotid duplex assessment, assessing CVR in the ICA was feasible, practical, and associated with high quality recordings. Differential associations with age between hypercapnic and hypocapnic stimuli imply a greater tendency to vasoconstriction in older patients.

Indexed as

Cerebrovascular reactivityextracranialfunctionstrokeultrasound

Identifiers

PMID42063926
PMCPMC13128087

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.