ArticleJACS Au2026
Total Syntheses of (+)-Hyperbeanols A-C, (+)-Hyperpatulol A, and (-)-Hypercohone G, as Well as Structure Revision of Hyperpatulol A, and Hyperbeanol B.
Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Hyperbeanols A-C, hyperpatulol A, and hypercohone G belong to spirocyclic polycyclic polyprenylated acylphloroglucinols (PPAPs). These natural products share the same unusual 6/6/5 spirocyclic skeleton and possess five stereocenters. The total syntheses of hyperbeanols A-C, hyperpatulol A, and hypercohone G have been accomplished. Among them, hyperbeanols B/C, hyperpatulol A, and hypercohone G were synthesized for the first time. The concise synthesis featured a Knoevenagel condensation to link two fragments and a Mn-(III)-mediated radical cyclization to construct the 6/6/5 spirocyclic skeleton. Besides, we also revised the structures of hyperpatulol A and hyperbeanol B.
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