ArticleJACS Au2026
Sulfur Ylide-Mediated Cascade Transformations to Access Cyclopropylallocolchicinoids with Potent Antimitotic Activity.
Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We present an efficient one-pot transformation for the synthesis of unprecedented classes of cyclopropyl-fused allocolchicinoids through the discovery of a new reactivity pattern of sulfoxonium ylides. This hybrid strategy rationally manipulates the nucleophilic character of sulfur ylides to achieve the regio- and stereoselective construction of structurally intriguing allocolchicinoids bearing multiple stereocenters. Notably, this methodology represents the first general approach to sp
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