Evidence map›Paper›PMID 42063819›Full record

ArticleJACS Au2026

Palladium-Catalyzed Enantioselective [4 + 2] Annulation with Allenes: Direct Access to Chiral Silatetralins.

Hang Zhou, Yan Sun, Rui Xu, Tao Chen, Liuzhou Gao, Guofeng Zhao, Junliang Zhang, Yidong Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hang ZhouSchool of Chemistry and Materials, Yangzhou University, Yangzhou, Jiangsu 225002, China.
Yan SunSchool of Chemistry and Materials, Yangzhou University, Yangzhou, Jiangsu 225002, China.
Rui XuSchool of Chemistry and Materials, Yangzhou University, Yangzhou, Jiangsu 225002, China.
Tao ChenSchool of Chemistry and Materials, Yangzhou University, Yangzhou, Jiangsu 225002, China.
Liuzhou GaoSchool of Chemistry and Materials, Yangzhou University, Yangzhou, Jiangsu 225002, China.ORCID https://orcid.org/0000-0002-5409-8248
Guofeng ZhaoSchool of Chemistry & Chemical Engineering, Henan University of Science and Technology, Luoyang 471003, China.
Junliang ZhangSchool of Chemistry and Materials, Yangzhou University, Yangzhou, Jiangsu 225002, China.ORCID https://orcid.org/0000-0002-4636-2846
Yidong WangSchool of Chemistry and Materials, Yangzhou University, Yangzhou, Jiangsu 225002, China.ORCID https://orcid.org/0000-0001-9560-3186

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chiral tetralins represent privileged scaffolds in medicinal chemistry, and the incorporation of silicon as a bioisostere offers a valuable strategy for molecular design. Nevertheless, efficient synthetic approaches to enantiopure silicon-bridged tetralin analogues remain highly desirable and underdeveloped. Herein, we present the strategy for constructing chiral silatetralins via a highly enantioselective palladium-catalyzed [4 + 2] annulation between benzosilacyclobutenes and a wide range of allenes by employing a chiral phosphoramidite ligand. The reaction is distinguished by exclusive proximal CC bond insertion of the allene and selective Si-C-(sp

Indexed as

allenesbenzosilacyclobutenesenantioselective synthesispalladium catalysissilatetralin

Identifiers

PMID42063819
PMCPMC13126167

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.