Evidence map›Paper›PMID 42063812›Full record

ArticleJACS Au2026

Human Milk Oligosaccharides Inhibit Group B Streptococcal Growth by Binding PcsB, an Essential Cell Wall Separation Protein.

Julie A Talbert, Thomas L Kalmer, Lee S Cantrell, Mithila D Bandara, Alexei V Demchenko, Allison S Walker, Jennifer A Gaddy, Steven D Townsend

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Julie A TalbertDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37240, United States.
Thomas L KalmerDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37240, United States.ORCID https://orcid.org/0009-0009-8178-2027
Lee S CantrellDepartment of Biochemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.
Mithila D BandaraDepartment of Chemistry, Saint Louis University, St. Louis, Missouri 63103, United States.
Alexei V DemchenkoDepartment of Chemistry, Saint Louis University, St. Louis, Missouri 63103, United States.ORCID https://orcid.org/0000-0003-3515-212X
Allison S WalkerDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37240, United States.ORCID https://orcid.org/0000-0001-5666-7232
Jennifer A GaddyDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.ORCID https://orcid.org/0000-0002-2192-4224
Steven D TownsendDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37240, United States.ORCID https://orcid.org/0000-0001-5362-7235

Funding

Bioorganic Approaches Toward Novel Antimicrobial Agents and ChemotherapeuticsR35GM133602 · NIGMS · VANDERBILT UNIVERSITY · PI Steven D. Townsend · 2019 to 2026
$3.0M
Machine learning approaches for the discovery, repurposing, and optimization of natural products with therapeutic potential - Supplement to support grad training of Adrian RussR35GM146987 · NIGMS · VANDERBILT UNIVERSITY · PI Allison Sara Walker · 2022 to 2026
$2.4M
Utility of human milk oligosaccharides against the perinatal pathogen, Group B StreptococcusR01HD113675 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jennifer A Gaddy, Steven D. Townsend · 2024 to 2026
$1.1M
NICHD NIH HHS R01 HD113675NIGMS NIH HHS R35 GM133602NIGMS NIH HHS R35 GM146987
6 · The paper itself

Abstract

Human milk oligosaccharides (HMOs) are complex sugars in breast milk that protect babies by preventing harmful bacteria from colonizing the gut. Our team extended the study of HMOs beyond the neonatal gut and characterized their antimicrobial activity against group B

Indexed as

cell wall separationgroup B Streptococcusmicroscale thermophoresisPcsBproteomics

Identifiers

PMID42063812
PMCPMC13126162

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.