ArticleFrontiers in medicine2026
Ultra-low fluence 532 nm picosecond laser treatment for acne scars: OCT-observed epidermal vacuole-like changes-a case report.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Background: Treating atrophic acne scars in Asian skin (Fitzpatrick types III-V) is challenging due to the elevated risk of post-inflammatory hyperpigmentation (PIH). While picosecond lasers with fractional handpiece treatment are effective, the optimal balance between fluence, passes, clinical outcome, and downtime remains controversial. Case presentation: A 28-years-old Asian male with moderate atrophic acne scars was treated with a 532-nm picosecond Nd:YAG laser using a fractional handpiece. An ultra-low fluence of 0.03 J/cm Results: Clinical follow-up demonstrated observable changes in scar contour and skin surface irregularity after a single treatment session, without downtime or PIH. Optical Coherence Tomography (OCT) revealed intraepidermal vacuole-like structures exclusively at the ultra-low setting (0.03 J/cm Conclusion: Ultra-low fluence, high-pulse-count 532-nm treatment may be associated with OCT-detectable intraepidermal vacuole-like response not observed at higher fluences. While the biological mechanism remains to be elucidated, these findings highlight the possibility of a non-linear dose-response phenomenon and support further investigation into sub-threshold treatment paradigms in pigment-prone populations.
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