ReviewFrontiers in medicine2026
Comparative efficacy and safety of medical and surgical management for missed miscarriage: a systematic review and meta-analysis.
Review in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Comparative evidence regarding the efficacy and safety of medical versus surgical management for missed miscarriage has not been consistently evaluated. Methods: The meta-analysis was in line with the PRISMA 2020 and MOOSE guidelines. The Web of Science, PubMed, Embase, and ScienceDirect databases were searched for eligible studies. The outcomes were the success rate, bleeding duration, infection rate and complication rate. The pooled results were synthesized via random-effect model. Influential publication was determined by performing sensitivity analysis. In addition, the potential sources of heterogeneity were examined by using subgroup analyses. Publication bias was assessed using the funnel plot, Begg's and Egger's tests. Results: The seven included studies (four RCTs and three cohort studies) were conducted between 1994 and 2025, with a total of 1,637 patients with missed miscarriage. We found that surgical management demonstrates superior clinical efficacy and safety compared to medical management, with higher success rate [risk difference (RD) = 0.26, 95% confidence interval (95% CI): 0.14 to 0.39, Conclusion: Surgical management demonstrates superior clinical efficacy and safety compared to medical management, especially in pregnancies with earlier gestational age. A truly patient-centered approach must balance individual preferences, gestational age, follow-up access, and awareness of clinical risks.
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