Evidence map›Paper›PMID 42063560›Full record

ArticleiScience2026

Impact of enteric neuronal loss on intestinal cell composition.

Naomi J M Kakiailatu, Wei Zhang, Laura E Kuil, Jonathan D Windster, Eric Bindels, Joke T M Zink, Michael Vermeulen, Bianca M de Graaf, Deepavali Sahadew, Thierry P P van den Bosch and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Naomi J M KakiailatuDepartment of Clinical Genetics, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands.
Wei ZhangDepartment of Clinical Genetics, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands.
Laura E KuilDepartment of Clinical Genetics, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands.
Jonathan D WindsterDepartment of Clinical Genetics, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands.
Eric BindelsDepartment of Hematology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Joke T M ZinkDepartment of Hematology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Michael VermeulenDepartment of Hematology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Bianca M de GraafDepartment of Clinical Genetics, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands.
Deepavali SahadewDepartment of Clinical Genetics, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands.
Thierry P P van den BoschDepartment of Pathology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands.
Demi HuijgenDepartment of Pediatric Surgery, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands.
Cornelius E J SlootsDepartment of Pediatric Surgery, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands.
Rene M H WijnenDepartment of Pediatric Surgery, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands.
Robert M W HofstraDepartment of Clinical Genetics, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands.
Emma de PaterDepartment of Hematology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Veerle MelotteDepartment of Clinical Genetics, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands.
Maria M AlvesDepartment of Clinical Genetics, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hirschsprung disease (HSCR) is a congenital disorder characterized by the absence of an enteric nervous system (ENS) in the distal gut. While the ENS is critical for normal gut function, its broader role in maintaining intestinal homeostasis remains underexplored. Using single-cell RNA sequencing, we investigated the impact of ENS loss on gut composition in wildtype and

Indexed as

Integrative aspects of cell biologyModel organismTranscriptomics

Identifiers

PMID42063560
PMCPMC13127327

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.