ArticleiScience2026
Real-time visualization of spatial and temporal coordination in resolvase-mediated Holliday junction binding.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- A simple suspension culture method for generating human iPSC-derived liver organoids.Biology methods & protocols · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Holliday junctions (HJs) are key intermediates in homologous recombination and must be processed with high precision to maintain genome stability. The bacterial resolvase RuvC has served as a model system to study this process. Here, we applied high-speed atomic force microscopy (HS-AFM) to directly visualize RuvC-DNA interactions at the single-molecule level and without the need for labeling, under near-physiological ionic conditions. HS-AFM revealed that RuvC exists as monomeric and dimeric species, and that binding to cruciform DNA mimicking HJs was associated with the dimeric form. Importantly, magnesium ions markedly enhanced the persistence of RuvC-HJ complexes, highlighting a structural role beyond catalysis. Structural predictions further supported that Mg
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.