Evidence map›Paper›PMID 42063534›Full record

ArticleJCO oncology advances2025

Development and Validation of a Natural Language Processing Algorithm Using Electronic Health Record Data to Identify Breast Cancer Patients With Low Social Support.

Candyce H Kroenke, Rhonda Aoki, Lauren Mammini, Stacey Alexeeff, Salene M W Jones, Lawrence H Kushi, Jessica Mogk, Shaila Strayhorn-Carter, David Mosen, David Cronkite and 1 more

Abstract read
In one paragraph

Article in JCO oncology advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Candyce H KroenkeDivision of Research, Kaiser Permanente Northern California, Pleasanton, CA.ORCID https://orcid.org/0000-0002-6128-3118
Rhonda AokiDivision of Research, Kaiser Permanente Northern California, Pleasanton, CA.ORCID https://orcid.org/0000-0003-0403-9968
Lauren MamminiDivision of Research, Kaiser Permanente Northern California, Pleasanton, CA.
Stacey AlexeeffDivision of Research, Kaiser Permanente Northern California, Pleasanton, CA.
Salene M W JonesFred Hutchinson Cancer Center, Seattle, WA.ORCID https://orcid.org/0000-0003-2140-5798
Lawrence H KushiDivision of Research, Kaiser Permanente Northern California, Pleasanton, CA.ORCID https://orcid.org/0000-0001-9136-1175
Jessica MogkKaiser Permanente Washington Health Research Institute, Seattle, WA.ORCID https://orcid.org/0000-0003-4102-7309
Shaila Strayhorn-CarterUniversity of North Carolina Wilmington, Wilmington, NC.ORCID https://orcid.org/0000-0003-4164-4788
David MosenKaiser Permanente Center for Health Research, Portland, OR.
David CronkiteKaiser Permanente Washington Health Research Institute, Seattle, WA.ORCID https://orcid.org/0000-0002-2797-5102
Kaiser Permanente Northern California Clinician Board

Funding

An Electronic Health Record-Based Tool to Identify Newly Diagnosed Breast Cancer Patients at Risk of Low Social SupportR01CA253028 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI KROENKE, CANDYCE H · 2020 to 2025
$2.6M
NCI NIH HHS R01 CA253028
6 · The paper itself

Abstract

purposeSocial support is important in the management of breast cancer. We developed a series of structured variables or modules from electronic health record (EHR) data to form the basis for the development of EHRsupport, an EHR-based measure of social support.

methodsWe built a natural language processing (NLP) algorithm from clinical notes in 7,989 women diagnosed from January 2006 to September 2021 with invasive breast cancer. Our team reviewed charts, developed a lexicon, manually crafted rules, applied the NLP algorithm to 565,258 EHR notes and 68,760 patient messages -1 to +3 months around diagnosis, combined terms into separate modules, and tuned (N = 40), updated, and tested (N = 100) these versus chart review. We further developed modules from structured data sources.

resultsWe identified and developed 11 modules from unstructured data: spouse/partner status, parenthood status, (clinical) visit support, living situation (alone or with others), friend or other support, positive social support, negative (lack of) social support, deceased person, transportation issues, relationship conflict or stress, and social isolation. Module data availability ranged from 1.4% for social isolation to 92.0% for spouse/partner. Modules were accurate (0.81-0.95). The most highly available groups had moderate to excellent F1 scores (0.75-1.00), precision or positive predictive value (0.61-1.00), and recall or sensitivity (0.75-1.00). Recall and precision were more variable among rarer modules. Five percent of patients lacked an in-state emergency contact and 3% of patients had diagnostic codes for low support at any time point.

conclusionThe EHRsupport algorithm accurately identified social support data, supporting the development of a clinical tool that can be used to identify patients with low social support.

Identifiers

PMID42063534
PMCPMC13128030

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.