ArticleMilitary Medical Research2026
Associations of Different Definitions of Prediabetes and Diabetes with All-Cause and Cause-Specific Mortality: A Nationally Representative Cohort Study.
Article in Military Medical Research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Joint association of Insulin resistance and frailty index with incident ASCVD and MACE in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: a multi-cohort study.Cardiovascular diabetology · 2026Observational
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Authors and funding
13 authors.
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Abstract
Background: The associations between different definitions of prediabetes and diabetes with mortality and life expectancy remain unclear. Clarifying these associations is essential for informing hyperglycemia management policies. We aimed to compare the prevalence of prediabetes and newly diagnosed diabetes across different glycemic indicators and diagnostic criteria, and to examine their associations with mortality and life expectancy. Methods: We analyzed data from 141,945 adults from a nationally representative cohort study in China. Cox proportional hazards regression models were used to estimate hazard ratios (HRs). Using fasting plasma glucose (FPG), 2-hour postload glucose (2hPG), and hemoglobin A1c (HbA1c) levels, prediabetes was defined according to the American Diabetes Association (ADA), World Health Organization (WHO), or International Expert Committee (IEC) criteria, and newly diagnosed diabetes according to the ADA criteria. Results: Prediabetes prevalence varied widely across glycemic indicators, ranging from 3.0% to 26.1%, while newly diagnosed diabetes prevalence ranged from 2.6% to 4.4%. Over a median follow-up of 9.0 years, a total of 6,924 deaths were documented. Compared with people with normoglycemia, prediabetes defined by FPG (either ADA or WHO criteria) was not significantly associated with increased risks of all-cause or cardiovascular disease (CVD) mortality (all Conclusions: These findings suggest that reliance on FPG alone may fail to identify certain individuals at elevated mortality risk. In contrast, 2hPG and HbA1c provide additional prognostic information beyond FPG.
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