ArticleFrontiers in pediatrics2026
TIBC, PLR, and EBV DNA load correlate with hepatic injury in EBV-associated infectious mononucleosis.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To analyze clinical features of hepatic injury in children with EBV-associated infectious mononucleosis (EBV-IM) and identify its risk factors. Methods: A retrospective analysis of the clinical data of children with EBV-IM admitted to the First Hospital of Jilin University from March 2023 to March 2025 was conducted. Confounding factors were balanced by propensity score matching (PSM). The children were divided into a hepatic injury group and a non-hepatic injury group. The risk factors were examined using binary logistic regression. Furthermore, the diagnostic performance of these risk factors was assessed and presented using receiver operating characteristic (ROC) curves. Results: After PSM, 52 pairs of patients were matched. Statistically significant differences in white blood cell count, the proportion of neutrophils, the proportion and absolute value of lymphocytes, the platelet-to-lymphocyte ratio (PLR), hepatosplenomegaly, whole blood EBV DNA load >1 × 10 Conclusion: EBV-IM-related hepatic injury in children correlates with iron metabolism. TIBC and whole blood EBV DNA load (>1 × 10
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