ArticleFrontiers in veterinary science2026
Non-anticoagulant heparin attenuates histone-mediated platelet-leukocyte aggregation and neutrophil extracellular trap formation in a canine whole blood model.
Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Neutrophil extracellular traps in cardiovascular disease: Mechanisms and therapeutic implications (Review).International journal of molecular medicine · 2026Review
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3 authors.
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Abstract
Introduction: Sepsis and systemic inflammatory response syndrome (SIRS) are major contributors to morbidity and mortality in dogs, with limited therapeutic advancements. A key factor in this disease progression is the excessive formation of neutrophil extracellular traps (NETs). This study aimed to evaluate the ability of non-anticoagulant heparin (NACH) and unfractionated heparin (UFH) to modulate NET formation and platelet-leukocyte, platelet-neutrophil interactions in an Methods: Eleven healthy staff-owned dogs were enrolled after confirmation of normal physical examinations and complete blood counts. Whole blood was collected and incubated with either calf thymus histone (0.5 mg/mL) or heated-killed Results: NACH at 10 μg/mL significantly reduced histone-induced platelet-leukocyte (29.0% ± 22.5) and platelet-neutrophil (22.7% ± 15.1) aggregates compared to vehicle controls (37.7% ± 23.7 and 31.8% ± 20.9; Conclusion: NACH effectively reduces histone-induced leukocyte and neutrophil-platelet aggregation, while UFH is more effective against
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