Evidence map›Paper›PMID 42063385›Full record

ArticleESC heart failure2026

Out-of-hours primary care management for patients with heart failure.

Anne P Nelissen, Sander van Doorn, Carline J van den Dries, Michelle Spek, Dorien L M Zwart, Roderick P Venekamp, Linda W van Laake, Frans H Rutten, Geert-Jan Geersing

Abstract read
In one paragraph

Article in ESC heart failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anne P NelissenDepartment of General Practice & Nursing Science, Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID 0009-0002-7870-6292
Sander van DoornDepartment of General Practice & Nursing Science, Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0003-4319-3503
Carline J van den DriesDepartment of General Practice & Nursing Science, Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0001-7602-3522
Michelle SpekDepartment of General Practice & Nursing Science, Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0002-5914-4231
Dorien L M ZwartDepartment of General Practice & Nursing Science, Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0003-0098-4882
Roderick P VenekampDepartment of General Practice & Nursing Science, Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0002-1446-9614
Linda W van LaakeDepartment of Cardiology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0002-5027-0661
Frans H RuttenDepartment of General Practice & Nursing Science, Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0002-5052-7332
Geert-Jan GeersingDepartment of General Practice & Nursing Science, Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0001-6976-9844

Funding

European Union'sHorizon Europe research and innovation program 101080905United Kingdom Research and Innovation 10073472
6 · The paper itself

Abstract

introductionLittle is known about the management and disease trajectories of heart failure (HF) patients in the pre-hospital setting when experiencing exacerbating symptoms. Shortness of breath (SOB) is a main reason for contacting out-of-hours primary care (OHS-PC). We aim to describe the care trajectories of these patients with HF at the OHS-PC with exacerbating symptom SOB and to assess 6-month outcomes regarding mortality and hospital admissions.

methodsWe included patients who contacted Dutch OHS-PC for SOB between September 2020 and August 2021. We selected those in whom HF was considered to be the cause for consultation and further clinical evaluation. We applied descriptive analyses to characterize these patients and their disease trajectories following this OHS-PC contact and compared patients referred to the Emergency Department (ED) to those who remained in primary care.

resultsOf 1833 calls for SOB, 102 (5.1%) concerned patients with HF, who had a mean age of 79.6 ± 11.1 years, and 53% were women. Ten (9.8%) patients were directly referred to the ED. The remaining 92 (90.2%) were first assessed by a general practitioner (GP): 62 (60.8%) received a home visit, 15 (14.7%) were seen at the OHS-PC clinic, and 15 (14.7%) received a telephone advice only. Of these 92 patients, 41 (44.6%) patients were subsequently referred to the ED, and 39 (42.4%) were kept at home and received loop diuretics (newly initiated or increased dose). Of the 51 patients referred to the ED (directly or after assessment with the GP), 42 patients (82.4%, P-value < .001) were admitted. Six-month all-cause mortality of the 102 patients was 32.3%.

conclusionAt the OHS-PC, one in every 20 contacts for SOB is a HF patient who has a high 6-month mortality risk. Patients were directly referred to the hospital or received initiation or up-titration of loop diuretics.

Indexed as

After-Hours CareDyspneaHeart FailureSodium Potassium Chloride Symporter InhibitorsAgedAged, 80 and overEmergency Service, HospitalFemaleHumansMaleNetherlandsPrimary Health CareSodium Potassium Chloride Symporter InhibitorsDecompensated heart failureDyspnoeaGeneral practiceHeart failureOut-of-hours primary careShortness of breath

Identifiers

PMID42063385
PMCPMC13202465

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.