Evidence map›Paper›PMID 42063362›Full record

ArticleJournal of applied toxicology : JAT2026

Mephedrene-Induced Cardiac Electrophysiological and Molecular Alterations: An Integrated In Vitro and In Vivo Study.

Min Gyeong Kim, Hyun Kyu Min, Si-Keun Lim, Ki Kyung Jung

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied toxicology : JAT, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Min Gyeong KimDepartment of Forensic Sciences, Graduate School of Sungkyunkwan University (Natural Sciences Campus), Suwon, South Korea.ORCID 0009-0002-8275-8386
Hyun Kyu MinPharmacological and Narcotics Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju, South Korea.
Si-Keun LimDepartment of Forensic Sciences, Graduate School of Sungkyunkwan University (Natural Sciences Campus), Suwon, South Korea.ORCID 0000-0003-4246-6223
Ki Kyung JungPharmacological and Narcotics Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju, South Korea.

Funding

National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Republic of Korea 24211MFDS222
6 · The paper itself

Abstract

Mephedrene, a psychoactive stimulant structurally related to methamphetamine, has recently emerged on illicit markets. Although methamphetamine-like compounds are known to stimulate the central nervous system and elevate cardiovascular risk, the pharmacological and toxicological characteristics of mephedrene, particularly its cardiotoxic potential, are poorly defined. Cardiotoxicity was evaluated using integrated in vitro and in vivo approaches. Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) were assessed for electrophysiological alterations by multi-electrode array (MEA) recordings, cell viability by WST-1 assay, and sarco/endoplasmic reticulum Ca

Indexed as

Central Nervous System StimulantsMethamphetamineMyocytes, CardiacAnimalsCardiotoxicityCell SurvivalDose-Response Relationship, DrugElectrocardiographyHumansInduced Pluripotent Stem CellsMaleRatsRats, Sprague-DawleySarcoplasmic Reticulum Calcium-Transporting ATPasesAtp2a2 protein, ratCentral Nervous System StimulantsMethamphetamineSarcoplasmic Reticulum Calcium-Transporting ATPasescardiotoxicityelectrocardiogram (ECG)mephedrene (5‐methylmethiopropamine)multi‐electrode array (MEA)SERCA2Western blot

Identifiers

PMID42063362
PMCPMC13532834

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.