Evidence map›Paper›PMID 42063332›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Functional Analysis of Ligand-Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling.

Abhilasha Ojha, Linda Kloss, Juan D Montenegro, Simone Albani, Audrey Ortega-Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Abhilasha OjhaInstitute of Physiology, RWTH Aachen University, Aachen, Germany.
Linda KlossDepartment of Neurosciences and Developmental Biology, Faculty of Life Sciences, University of Vienna, Vienna, Austria.ORCID https://orcid.org/0009-0008-4702-0742
Juan D MontenegroDepartment of Neurosciences and Developmental Biology, Faculty of Life Sciences, University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0003-4898-5761
Simone AlbaniInstitute for Neuroscience and Medicine (INM-9), Computational Biomedicine, Forschungszentrum Jülich, Jülich, Germany.ORCID https://orcid.org/0000-0002-3560-4539
Audrey Ortega-RamírezInstitute of Physiology, RWTH Aachen University, Aachen, Germany.
Mihaela RaychevaInstitute of Clinical Pharmacology, RWTH Aachen University, Aachen, Germany.
Sylvia JoussenInstitute of Physiology, RWTH Aachen University, Aachen, Germany.
Sabrina KaulDepartment of Neurosciences and Developmental Biology, Faculty of Life Sciences, University of Vienna, Vienna, Austria.
Michèle BachmannInstitute of Physiology, RWTH Aachen University, Aachen, Germany.
Lisa HufDepartment of Neurosciences and Developmental Biology, Faculty of Life Sciences, University of Vienna, Vienna, Austria.
Günther SchmalzingInstitute of Clinical Pharmacology, RWTH Aachen University, Aachen, Germany.
Alison G ColeDepartment of Neurosciences and Developmental Biology, Faculty of Life Sciences, University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0002-7515-7489
Ulrich TechnauDepartment of Neurosciences and Developmental Biology, Faculty of Life Sciences, University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0003-4472-8258
Stefan GründerInstitute of Physiology, RWTH Aachen University, Aachen, Germany.ORCID https://orcid.org/0000-0002-7635-9883

Funding

Austrian Science Fund FWF P34970Deutsche Forschungsgemeinschaft GR1771/8-1Deutsche Forschungsgemeinschaft Schm536/12-1EVONeuroMuscle 101142107
6 · The paper itself

Abstract

γ-aminobutyric acid (GABA) is the predominant inhibitory transmitter in the vertebrate nervous system. Fast inhibitory signaling is mediated by type A GABA receptors (GABA

Indexed as

Chloride ChannelsCnidariagamma-Aminobutyric AcidLigand-Gated Ion ChannelsReceptors, GABA-ASignal TransductionAnimalsEvolution, MolecularMutagenesis, Site-DirectedPhylogenyChloride Channelsgamma-Aminobutyric AcidLigand-Gated Ion ChannelsReceptors, GABA-Acnidariacys‐loop receptorsGABAGABAA receptorsglutamate‐gated ion channelsligand‐gated ion channelsNematostella

Identifiers

PMID42063332
PMCPMC13335744

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.