ArticleInterdisciplinary cardiovascular and thoracic surgery2026
The NAVIGATE Registry: Early Endovascular Repair of the Ascending Aorta With the Nexus Ascending Module.
Article in Interdisciplinary cardiovascular and thoracic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesOpen repair remains the standard for ascending aortic pathology but carries high morbidity in frail or inoperable patients. This study evaluates the feasibility and early outcomes of endovascular repair using the Nexus Ascending Module, a CE-marked device designed for zone 0.
methodsNAVIGATE is a retrospective multicentre European registry including 8 high-risk patients treated between 2023 and 2025 across 6 tertiary centres. All had focal zone 0 pathology and were deemed unsuitable for open repair. Procedures were planned with ECG-gated CT angiography and performed transfemorally. Technical success, perioperative complications, 30-day mortality, and follow-up outcomes were assessed.
resultsMedian age was 80.0 years (IQR: 59.5-80.5), and 87.5% had prior cardiac surgery. The median EuroSCORE II was 24.0% (IQR: 19.7%-44.0%). Pathologies included contained rupture/pseudoaneurysm (n = 4), mycotic pseudoaneurysm (n = 3), and type A DeBakey II dissection (n = 1). Technical success was achieved in all patients; 2 required immediate overlapping stent-grafts for complete sealing. No stroke, valve dysfunction, coronary compromise, tamponade, type I/III endoleak, conversion to surgery, or in-hospital/30-day mortality occurred. One access-related complication was observed.Median ICU and hospital stays were 1 and 5 days. At a median follow-up of 15 months (IQR: 12-24), no aortic reinterventions or device-related complications occurred. Two patients died from respiratory disease (12 months) and persistent infection (4 months).
conclusionsThis small multicentre case series suggests that endovascular repair of isolated zone 0 ascending pathology using the Nexus Ascending Module is technically feasible in highly selected patients; however, these findings are preliminary and hypothesis-generating.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.