Evidence map›Paper›PMID 42062952›Full record

ArticleBMC ophthalmology2026

Retinal vasculitis as a presenting sign of Epstein-Barr virus positive diffuse large B-cell lymphoma: a case report.

Negin Yavari, MohammadBagher Rajabi, Dalia El Feky, Isabel Sendino-Tenorio, Gunay Uludag Kirimli, Jia-Horung Hung, Nathan Shows, Amir Akhavanrezayat, Osama Elaraby, Ngoc Than and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Negin YavariByers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
MohammadBagher RajabiByers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Dalia El FekyByers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Isabel Sendino-TenorioDepartment of Ophthalmology, Complejo Asistencial Universitario de Leon, Leon, Spain.
Gunay Uludag KirimliByers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Jia-Horung HungByers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Nathan ShowsByers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Amir AkhavanrezayatByers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Osama ElarabyByers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Ngoc ThanByers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Azadeh MobasserianByers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Christopher OrByers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA. chrisor@stanford.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo present a case of bilateral retinal vasculitis associated with diffuse large B-cell lymphoma (DLBCL). CASE PRESENTATION: A 28-year-old Asian male presented with irritation, a foreign body sensation, and blurry vision in his left eye. While in India, he experienced back pain and a left-sided neck nodule, which was assessed via ultrasound and considered idiopathic. Ocular examination revealed peripheral vascular sheathing bilaterally. Fluorescein angiography demonstrated small areas of hyperfluorescence around the nasal foveal vessels, mild vasculitis in the right eye, and prominent vasculitis in the left eye. A physical exam identified lymphadenopathy in the cervical chain. Therefore, a chest CT was performed which showed possible lymphoproliferative/metastatic disease or granulomatous infection followed by PET-CT demonstrating splenic, bone marrow, and extralymphatic organ involvement. An initial core biopsy of the left supraclavicular lymph node was performed and revealed rare, atypical large CD30 + lymphoid cells suggestive of Non-Hodgkin lymphoma, along with CD20 + large, atypical B-cells. A subsequent excisional biopsy confirmed Epstein-Barr Virus (EBV)+ DLBCL, stage IV. Following chemotherapy, retinal vasculitis resolved, and vision remained stable.

conclusionsAlthough rare, retinal vasculitis can serve as an early manifestation of EBV+ DLBCL. Its diagnosis is particularly challenging due to its ability to mimic other conditions. However, maintaining a high index of suspicion, comprehensive physical exam, and initiating aggressive treatment are essential.

Indexed as

Epstein-Barr Virus InfectionsEye Infections, ViralHerpesvirus 4, HumanLymphoma, Large B-Cell, DiffuseRetinal VasculitisAdultFluorescein AngiographyHumansMaleDiffuse large B-cell lymphomaEpstein-Barr virus-positiveNon-Hodgkin lymphomaRetinal vasculitis

Identifiers

PMID42062952
PMCPMC13277175

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.