ArticleBMC cardiovascular disorders2026
Diagnostic and prognostic value of miR-885-5p in acute coronary syndrome and its regulatory mechanisms in endothelial injury.
Article in BMC cardiovascular disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAcute coronary syndrome (ACS) is a common emergency in the cardiovascular system. The prevention, diagnosis, and treatment of ACS are critical and continuous issues in the clinic. Identifying non-invasive and promising biomarkers for ACS is of great clinical significance. This study evaluated the significance of miR-885-5p in the early screening, severity evaluation, and prognosis prediction of ACS, aiming to explore novel biomarkers for its clinical management.
methodsSerum miR-885-5p levels were compared between 134 ACS patients and 122 non-ACS patients. The clinical significance of miR-885-5p was assessed from the perspectives of discriminating ACS patients, risk prediction, severity evaluation, and prognosis prediction. In vitro, the ox-LDL-induced HCAEC models were employed, and the regulatory effects of miR-885-5p on cell viability, inflammation, oxidative stress, and endothelial function were estimated. The regulatory mechanism was explored, focusing on the involvement of FBXO28.
resultsIncreasing serum miR-885-5p could discriminate ACS patients and predict onset risk. miR-885-5p was positively correlated with myocardial injury-, severity-, and endothelial dysfunction-related clinicopathological features and could predict the risk of MACEs in ACS patients. In HCAECs, ox-LDL induced significant upregulation of miR-885-5p, suppressed cell viability, enhanced inflammation, promoted oxidative stress, and induced endothelial injury. Silencing miR-885-5p could protect HCAECs from ox-LDL-induced injury. FBXO28 was predicted as a direct target of miR-885-5p, negatively regulated by miR-885-5p. The knockdown of FBXO28 could reverse the protective effect of miR-885-5p silencing.
conclusionsCirculating miR-885-5p served as a biomarker for the diagnosis and prognosis of ACS. Silencing miR-885-5p could alleviate ox-LDL-induced endothelial cell injury by targeting FBXO28.
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