ArticleBMC pediatrics2026
Recurrence of febrile convulsions in children treated with intermittent benzodiazepines: a retrospective study investigating predisposing factors.
Article in BMC pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionFebrile seizures are the most common neurologic disorder in infants and young children, affecting 2-4% of those under six years of age. Although their overall prognosis is benign, recurrence is frequent and a major concern for families. This study aimed to identify factors associated with recurrence despite intermittent benzodiazepine prophylaxis.
methodWe conducted a retrospective cohort study at Tehran Children's Medical Center including 76 children aged 6-60 months with febrile seizures who were discharged on intermittent benzodiazepine therapy. The primary outcome was recurrence despite treatment. Clinical and laboratory variables were compared between recurrence and non-recurrence groups using logistic regression.
resultsFebrile seizures recurred in 20 of 76 children (26.3%). Age at first febrile seizure was significantly lower in the recurrence group (p-value = 0.001), and a history of previous febrile seizures was associated with recurrence (p = 0.018). Hyponatremia was also more frequent among recurrent cases (p-value = 0.003). In multivariable analysis, lower serum sodium (OR 0.713; 95% CI 0.518-0.981; p = 0.038) and younger age at first febrile seizure (OR 0.902; 95% CI 0.818-0.995; p = 0.039) remained independent predictors.
conclusionYounger age at first seizure and lower serum sodium were associated with recurrence despite intermittent benzodiazepine prophylaxis. These findings may help identify children at higher risk of treatment failure and guide counselling of families considering prophylaxis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.