ArticleInternational journal of epidemiology2026
Acute-phase reactants as predictors of chronic kidney disease incidence in Africans: the population-based prospective RODAM cohort study.
Article in International journal of epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
backgroundChronic kidney disease (CKD) and chronic inflammation are highly prevalent in African populations, yet their relationship remains understudied. We examined the association between acute-phase reactants (C-reactive protein and ferritin) as markers of acute and chronic inflammation and the incidence of CKD 6 years later in a prospective Ghanaian population-based cohort.
methodsData from the prospective Research on Obesity and Diabetes among African Migrants (RODAM-Pros) cohort were analysed and included participants living in rural and urban Ghana and Ghanaian migrants in the Netherlands. Acute-phase reactants were assessed between 2012 and 2015, while CKD incidence was assessed between 2019 and 2021 by using the race-free Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) 2021 equation. Robust Poisson regression models adjusted for potential confounders were used to assess associations. We explored interactions with age, sex, education, and geographical location, and stratified C-reactive protein (CRP) analyses by using established clinical cutoffs. The role of ferritin as an iron-storage marker was also evaluated.
resultsAmong 1435 participants, the baseline CRP was not associated with CKD incidence at follow-up [adjusted incidence rate ratio (aIRR) 1.02; 95% confidence interval (CI): 0.84-1.15]. Higher ferritin levels were associated with increased CKD risk (aIRR 3.53; 95% CI: 2.42-5.01) and albuminuria (aIRR 4.22; 95% CI: 2.87-6.10), but not with reduced estimated glomerular filtration rate (aIRR 0.99; 95% CI: 0.92-1.05). No effect modification was observed by age, sex, education, or geographical location. We found no evidence that iron overload or deficiency contributed to the ferritin-CKD relationship.
conclusionElevated ferritin levels, but not CRP levels, were associated with future CKD risk in Ghanaians. Multi-population prospective studies with repeated ferritin measurements are needed to better understand the links between ferritin, iron status, and CKD in African populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.