Evidence map›Paper›PMID 42062661›Full record

ArticleOncology and therapy2026

Occupational Variation in the Incidence of Laryngeal Cancer in the Nordic Countries.

Timo Carpén, Zakarya Hadj-Allal, Rayan Nikkilä, Johnni Hansen, Sanna Heikkinen, Elsebeth Lynge, Jan Ivar Martinsen, Jenny Selander, Ingrid Sivesind Mehlum, Marcin W Wojewodzic and 3 more

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Article in Oncology and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Timo CarpénDepartment of Otorhinolaryngology-Head and Neck Surgery, and Research Program in Systems Oncology, University of Helsinki, and HUS Helsinki University Hospital, P.O. Box 263, 00029 HUS, Helsinki, Finland.
Zakarya Hadj-AllalDepartment of Otorhinolaryngology-Head and Neck Surgery, and Research Program in Systems Oncology, University of Helsinki, and HUS Helsinki University Hospital, P.O. Box 263, 00029 HUS, Helsinki, Finland.
Rayan NikkiläDepartment of Otorhinolaryngology-Head and Neck Surgery, and Research Program in Systems Oncology, University of Helsinki, and HUS Helsinki University Hospital, P.O. Box 263, 00029 HUS, Helsinki, Finland.
Johnni HansenDanish Cancer Society Research Center, Copenhagen, Denmark.
Sanna HeikkinenFinnish Cancer Registry, Institute for Statistical and Epidemiological Cancer and Research, Helsinki, Finland.
Elsebeth LyngeNykøbing Falster Hospital, University of Copenhagen, Nykøbing Falster, Denmark.
Jan Ivar MartinsenDepartment of Research, Cancer Registry of Norway, Norwegian Institute of Public Health, Oslo, Norway.
Jenny SelanderInstitute of Environmental Medicine, IMM Karolinska Institutet, Stockholm, Sweden.
Ingrid Sivesind MehlumNational Institute of Occupational Health (STAMI), Oslo, Norway.
Marcin W WojewodzicDepartment of Research, Cancer Registry of Norway, Norwegian Institute of Public Health, Oslo, Norway.
Jóhanna Eyrún TorfadottirIcelandic Cancer Registry, Reykjavik, Iceland.
Antti MäkitieDepartment of Otorhinolaryngology-Head and Neck Surgery, and Research Program in Systems Oncology, University of Helsinki, and HUS Helsinki University Hospital, P.O. Box 263, 00029 HUS, Helsinki, Finland. antti.makitie@helsinki.fi.
Eero PukkalaFinnish Cancer Registry, Institute for Statistical and Epidemiological Cancer and Research, Helsinki, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionLaryngeal cancer (LC) constitutes almost one third of the head and neck cancers, and its main risk factors, alcohol use and smoking, are well established. Our aim was to explore the variation in the incidence of LC between different occupations.

methodsThis study was based on data from the Nordic Occupational Cancer Study (NOCCA), involving 14.9 million individuals from Denmark, Finland, Iceland, Norway, and Sweden. Occupational data from censuses were linked to cancer registry data from a period of up to 45 years (21,166 LC diagnoses) using personal identity codes. Standardized incidence ratios (SIRs) were calculated for different occupations, using the respective national populations as a reference.

resultsOf the 21,166 patients with LC, 18,488 (87%) were men. The highest SIRs in men were noted among waiters (3.31, 95% confidence interval [CI] 2.69-4.02), beverage workers (2.51, 95% CI 1.91-3.24), and cooks and stewards (2.25, 95% CI 1.82-2.74). Among women, the highest SIRs were observed among building hands (7.37, 95% CI 3.53-13.55) and public safety workers (3.60, 95% CI 1.17-8.40). Farming and teaching occupations showed reduced SIRs in both sexes. The SIRs among male farmers, teachers, gardeners, and technical workers were reduced in all countries. The SIRs remained elevated and stable among cooks and stewards, waiters, packers, seamen, sales agents, and economically inactive males across the three 15-year periods from 1961 to 2005.

conclusionThe study confirms a major variation in the incidence of LC between occupations. The findings underscore the importance of considering lifestyle factors typical of each occupation in cancer risk assessments and the potential benefits of targeted prevention efforts.

Indexed as

Head and neck neoplasmsIncidenceLaryngeal neoplasmsOccupational exposureRisk

Identifiers

PMID42062661
PMCPMC13303999

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.