Evidence map›Paper›PMID 42062597›Full record

ArticleNature neuroscience2026

Laminar organization of cellular microcircuits modulating human interictal epileptiform discharges.

Alexander B Silva, Siddharth A Marathe, Quinn R Greicius, Duo Xu, Shailee Jain, Jason E Chung, Xiaofang Yang, Ankit N Khambhati, Matthew K Leonard, Jonathan K Kleen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alexander B SilvaDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-0838-4136
Siddharth A MaratheDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Quinn R GreiciusDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3899-9855
Duo XuDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-8259-8688
Shailee JainDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7327-5492
Jason E ChungDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-1591-584X
Xiaofang YangDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Ankit N KhambhatiDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6182-4677
Matthew K LeonardDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Jonathan K Kleen *Weill Institute for Neuroscience, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-2622-3205
Edward F Chang *Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA. edward.chang@ucsf.edu.ORCID http://orcid.org/0000-0003-2480-4700

Funding

Functional organization of the superior temporal gyrus for speech perceptionR01DC012379 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Edward Chang · 2012 to 2026
$8.3M
Hippocampal-cortical networks underlying memory retrieval of linguistic knowledgeK23NS110920 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KLEEN, JONATHAN · 2019 to 2023
$1.0M
Developing a bilingual speech neuroprosthesisF30DC021872 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alexander Budugur Silva · 2024 to 2026
$139k
NIDCD NIH HHS F30 DC021872NIDCD NIH HHS R01 DC012379NINDS NIH HHS K23 NS110920
6 · The paper itself

Abstract

Interictal epileptiform discharges (IEDs) are pathological bursts of brain activity between seizures in people with epilepsy. Despite their importance in diagnosis, cognitive comorbidities and therapeutic implications as biomarkers for neurostimulation, it is unknown how IEDs arise from structured large-scale neuronal firing across human cortical lamina. We used high-density Neuropixels probes to record from epileptogenic tissue in patients undergoing resective surgery, sampling 1,152 neurons during 1,094 IEDs across nine neocortical sites. We identified microcircuits for IEDs organized by firing pattern, neocortical depth and putative cell type. Regular-spiking cells, concentrated in superficial cortical lamina, initiated and coded the amplitude of the sharp discharge and excitatory-inhibitory imbalances across neocortical lamina preceded IEDs, enabling IED prediction up to 1,000 ms in advance. Most neurons that were modulated during IEDs also encoded cognitive information and adhered to physiological rhythms at baseline. Thus, neocortical IEDs are generated from predictable laminar-cellular interactions, providing the groundwork for new neurostimulation therapies that harness the granularity of single neurons.

Indexed as

EpilepsyNeocortexNerve NetNeuronsAction PotentialsAdultElectroencephalographyFemaleHumansMaleYoung Adult

Identifiers

PMID42062597
PMCPMC13246451

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.