Evidence map›Paper›PMID 42062590›Full record

Articlenpj antimicrobials and resistance2026

Accelerating natural product discovery with linked MS-genomics and language/transformer-based models.

Dillon W P Tay, Winston Koh, Shi Jun Ang, Zicong Marvin Wong, Yi Wee Lim, Elena Heng, Yu Hung Ng, Naythan Z X Yeo, Krishnan Adaikkappan, Fong Tian Wong and 1 more

Abstract read
In one paragraph

Article in npj antimicrobials and resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dillon W P Tay *Institute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science Technology and Research (A*STAR), 8 Biomedical Grove, #07-01 Neuros Building, 138665, Singapore, Republic of Singapore. dillon_tay@a-star.edu.sg.
Winston Koh *Institute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science Technology and Research (A*STAR), 8 Biomedical Grove, #07-01 Neuros Building, 138665, Singapore, Republic of Singapore. Winston_Koh@a-star.edu.sg.
Shi Jun AngInstitute of High Performance Computing (IHPC), Agency for Science, Technology and Research (A*STAR), 1 Fusionopolis Way, #16-16 Connexis, 138632, Singapore, Republic of Singapore.
Zicong Marvin WongInstitute of High Performance Computing (IHPC), Agency for Science, Technology and Research (A*STAR), 1 Fusionopolis Way, #16-16 Connexis, 138632, Singapore, Republic of Singapore.
Yi Wee LimInstitute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science Technology and Research (A*STAR), 8 Biomedical Grove, #07-01 Neuros Building, 138665, Singapore, Republic of Singapore.
Elena HengInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, #07-06, Proteos, 138673, Singapore, Republic of Singapore.
Yu Hung NgInstitute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science Technology and Research (A*STAR), 8 Biomedical Grove, #07-01 Neuros Building, 138665, Singapore, Republic of Singapore.
Naythan Z X YeoInstitute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science Technology and Research (A*STAR), 8 Biomedical Grove, #07-01 Neuros Building, 138665, Singapore, Republic of Singapore.
Krishnan AdaikkappanInstitute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science Technology and Research (A*STAR), 8 Biomedical Grove, #07-01 Neuros Building, 138665, Singapore, Republic of Singapore.
Fong Tian WongInstitute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science Technology and Research (A*STAR), 8 Biomedical Grove, #07-01 Neuros Building, 138665, Singapore, Republic of Singapore. wong_fong_tian@a-star.edu.sg.
Yee Hwee LimInstitute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science Technology and Research (A*STAR), 8 Biomedical Grove, #07-01 Neuros Building, 138665, Singapore, Republic of Singapore. lim_yee_hwee@a-star.edu.sg.

Funding

Agency for Science, Technology and Research C211917003Agency for Science, Technology and Research C233017006National Research Foundation Singapore NRF-CRP19-2017-05-00
6 · The paper itself

Abstract

Integrated chem-bio characterization of microbial strain libraries can streamline natural product discovery by prioritizing candidate producers. Here, we employ language- and transformer-based models to extract actionable insights from linked mass spectrometry (MS)-genome datasets. Our framework enables ranking of microbial producers to prioritise high-potential candidates for targeted validation. Across three representative case studies, this approach prioritized producers of diverse natural products with 75-100% precision. These findings demonstrate the transformative potential of AI-enabled chem-bio characterization to significantly accelerate natural product discovery and enable access to microbial chemical diversity beyond reference knowledge.

Identifiers

PMID42062590
PMCPMC13133275

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.