Evidence map›Paper›PMID 42062580›Full record

ArticleScientific reports2026

Hydroxysafflor yellow A attenuatesovariectomy induced bone loss andpromotes osteogenesis via PI3K/AKT activation in an in vitro BMSC model.

Mingzhou Wu, Wei Wang, Zhongwei Ji, Kai Zheng, Weicheng Zhang, Gaoran Ge, Chunyang Fan, Dechun Geng, Yaozeng Xu, Jun Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mingzhou Wu *Department of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, China.
Wei Wang *Department of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, China.
Zhongwei Ji *Department of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, China.
Kai ZhengDepartment of Orthopedics, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361005, China.
Weicheng ZhangDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, China.
Gaoran GeDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, China.
Chunyang FanDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, China.
Dechun GengDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, China. szgengdc@suda.edu.cn.
Yaozeng XuDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, China. xuyaozeng@suda.edu.cn.
Jun ZhouDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, China. zhoujun@suda.edu.cn.

Funding

Natural Science Foundation of Fujian Province 2025J08306Program of Xiamen Health Commission 2024GZL-QN016Suzhou Applied Basic Research (Medical and Health) Youth Project SYWD2024188the Basic Research on Medical and Health Application in Taicang TC2024JCYL14the Basic Research Program of Medical Application in Suzhou SKYD2023238the Basic Research Project of Medical Innovative Application in Suzhou SKYD2023071the Key Project of "Strengthening Health through Science and Education" in Suzhou ZDXM2024001the National Natural Science Foundation of China 82502879the Natural Science Foundation of Nanjing University of Traditional Chinese Medicine XZR2024069the Special Project of Diagnosis and Treatment Technology for Key Clinical Diseases in Suzhou LCZX202302
6 · The paper itself

Abstract

Osteoporosis (OP) is a chronic systemic metabolic bone disorder that requires further exploration of effective treatments. An optimal anti-osteoporosis agent should exert dual effects on both osteoblasts and osteoclasts. Hydroxysafflor yellow A (HSYA), a flavonoid from the traditional Chinese medicinal plant safflower, is recognized as a potential candidate. This study shows that HSYA supports bone formation by stimulating osteoblast differentiation and increasing calcium nodule deposition. HSYA activates the PI3K/AKT signaling pathway and upregulates Runx2 expression in an in vitro osteoblast differentiation model using BMSCs. Concurrently, HSYA inhibit osteoclast differentiation, thereby mitigating the excessive bone resorption associated with osteoporosis. These findings indicate that HSYA mitigates bone loss in OP in vivo, while enhancing osteoblast activity and activating the PI3K/AKT pathway in an in vitro osteoblast differentiation model using BMSCs, and inhibiting osteoclast-driven bone resorption.

Indexed as

Bone ResorptionChalconeMesenchymal Stem CellsOsteogenesisOsteoporosisPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktQuinonesAnimalsCell DifferentiationCore Binding Factor Alpha 1 SubunitFemaleOsteoblastsOsteoclastsRatsSignal TransductionChalconeCore Binding Factor Alpha 1 Subunithydroxysafflor yellow APhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktQuinonesHydroxysafflor yellow AOsteoblastOsteoclastOsteoporosisPI3K

Identifiers

PMID42062580
PMCPMC13324341

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.