Evidence map›Paper›PMID 42062562›Full record

ArticleNature immunology2026

The long noncoding RNA lnc13 restrains inflammatory responses to maintain oral tolerance to gluten.

Ruxiao Yang-Fischer, Alyssa Shearer, Felipe Batista Leão, Izei Pascual-Gonzalez, Arnold Han, Ainara Castellanos-Rubio, Govind Bhagat, Sankar Ghosh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ruxiao Yang-FischerDepartment of Microbiology and Immunology, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.
Alyssa ShearerDepartment of Microbiology and Immunology, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.
Felipe Batista LeãoDepartment of Microbiology and Immunology, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.ORCID http://orcid.org/0000-0002-4130-8998
Izei Pascual-GonzalezDepartment of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country UPV/EHU, Leioa, Spain.ORCID http://orcid.org/0009-0006-4665-0828
Arnold HanDepartment of Microbiology and Immunology, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.
Ainara Castellanos-RubioDepartment of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country UPV/EHU, Leioa, Spain.ORCID http://orcid.org/0000-0003-3192-9544
Govind BhagatDepartment of Pathology and Cell Biology, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.ORCID http://orcid.org/0000-0001-6250-048X
Sankar GhoshDepartment of Microbiology and Immunology, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA. sg2715@columbia.edu.ORCID http://orcid.org/0000-0002-3227-0588

Funding

Understanding the Role of a Long Noncoding RNA in Celiac DiseaseR01DK102180 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GHOSH, SANKAR · 2014 to 2018
$1.8M
NIDDK NIH HHS R01 DK102180U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01DK142438-01
6 · The paper itself

Abstract

Celiac disease (CeD) is an autoimmune disorder triggered by dietary gluten. While HLA-DQ2/8-mediated presentation of gliadin peptides is required for disease, the mechanisms that underlie the loss of oral tolerance to gluten remain incompletely understood. Long-noncoding RNAs (lncRNAs) have been increasingly recognized as regulators of immune function, yet their role in oral tolerance has not been previously explored. Here, using a screen designed to identify lncRNAs responsive to T cell activation and enriched for CeD-associated GWAS variants, we identified lnc13 as a top candidate. In HLA-DQ8 transgenic mice lacking lnc13, unmanipulated gluten ingestion led to molecular signatures resembling human CeD and hallmark features of loss of oral tolerance to gluten: increased IFN-γ

Indexed as

Celiac DiseaseGlutensImmune ToleranceInflammationRNA, Long NoncodingAnimalsHLA-DQ AntigensHumansInterleukin-15Lymphocyte ActivationMiceMice, KnockoutMice, TransgenicGlutensHLA-DQ8 antigenHLA-DQ AntigensInterleukin-15RNA, Long Noncoding

Identifiers

PMID42062562
PMCPMC13226080

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.