ArticleInternational journal of obesity (2005)2026
Association of childhood-to-adulthood body size trajectories with cardiovascular risk and all cause mortality.
Article in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- ASN Kidney Health Guidance on the Cardiovascular-Kidney-Metabolic Syndrome.Journal of the American Society of Nephrology : JASN · 2026Guideline
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe relationship between body size across the life course and risks of cardiovascular disease (CVD) and mortality remains incompletely understood, particularly regarding transitions from childhood to adulthood and potential sex-specific differences. We examined the independent and joint associations of childhood body size, adulthood body mass index (BMI), and life-course body size trajectories with incident CVD and mortality.
methodsWe analyzed data from 456,461 UK Biobank participants free of CVD at baseline. Childhood body size at age 10 was self-reported as thinner, about average, or plumper relative to peers. Adulthood BMI was measured and classified as normal weight (<25 kg/m²), overweight (25-29.9 kg/m²), or obesity (≥30 kg/m²). Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident CVD-including stroke, coronary artery disease (CAD), and heart failure (HF)-and all-cause and cause-specific mortality. Sex-stratified analyses were conducted to assess effect modification.
resultsDuring follow-up, 2703 participants developed stroke, 13,349 HF, and 37,365 CAD. Compared with average childhood body size, plumper childhood was associated with higher risks of HF (HR 1.21, 95% CI 1.14-1.28) and CAD (HR 1.08, 95% CI 1.04-1.11). Adulthood obesity was strongly associated with HF (HR 1.91, 95% CI 1.80-2.02), CAD (HR 1.59, 95% CI 1.53-1.64), and all-cause mortality (HR 1.16, 95% CI 1.12-1.20). Life-course transitions toward obesity showed the highest risks, particularly for thinner-to-obesity trajectories (HF: HR 2.18, 95% CI 2.00-2.39; CAD: HR 1.72, 95% CI 1.62-1.81; all-cause mortality: HR 1.21, 95% CI 1.14-1.28). Associations with stroke were weaker and mainly observed for thinner-to-obesity transitions (HR 1.24, 95% CI 1.02-1.52). Associations were generally stronger in women.
conclusionBody size across the life course is associated with CVD and mortality, with progression to obesity from childhood to adulthood conferring the greatest risk. These findings support life-course and sex-sensitive obesity prevention strategies.
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