Evidence map›Paper›PMID 42062524›Full record

ArticlePediatric research2026

Intermittent hypoxemia metrics enhance bronchopulmonary dysplasia severity predictions in extremely low gestational age newborns.

Ananta Wadhwa, Jack Chang, Irina Prelipcean, Colby Day, Igor Khodak, Nancy E Roberston, Charles Rosenberg, Divya Chhabra, Andrew M Dylag

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Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Ananta WadhwaDepartment of Pediatrics, University of Rochester, Rochester, NY, USA.
Jack ChangClinical & Translational Science Institute, University of Rochester, Rochester, NY, USA.
Irina PrelipceanDepartment of Pediatrics, University of Rochester, Rochester, NY, USA.
Colby DayDepartment of Pediatrics, University of Rochester, Rochester, NY, USA.
Igor KhodakDepartment of Pediatrics, University of Rochester, Rochester, NY, USA.
Nancy E RoberstonClinical & Translational Science Institute, University of Rochester, Rochester, NY, USA.
Charles RosenbergClinical & Translational Science Institute, University of Rochester, Rochester, NY, USA.
Divya ChhabraDepartment of Pediatrics, University of Rochester, Rochester, NY, USA.
Andrew M DylagDepartment of Pediatrics, University of Rochester, Rochester, NY, USA. andrew_dylag@urmc.rochester.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPremature newborns experience intermittent hypoxemia (IH) events during their birth hospitalization. The objective of the study was to determine if IH event frequency and duration are associated with improved prediction of Bronchopulmonary Dysplasia (BPD) severity in Extremely Low Gestational Age Newborns (ELGANs, <29 weeks gestation).

methodsVariables were extracted from an ELGAN data repository (N = 342) containing real-time data views from the electronic medical record and N = 115 with Q1-minute vital signs. IH was defined as a "SpO

resultsIH duration, time spent below SpO

conclusionsInfants with worse BPD severity experience longer IH events. Some BPD severity predictions are enhanced when IH metrics are included. IMPACT: Intermittent hypoxemia event frequency and duration have distinct trajectories over time. Adding intermittent hypoxemia to bronchopulmonary dysplasia models based on the Neonatal Research Network 2019 definition enhances the prediction of BPD severity at postnatal day 28, suggesting bedside monitoring data can help distinguish BPD endotypes earlier in disease progression.

Identifiers

PMID42062524

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