ArticlePediatric research2026
Intergenerational continuity of parent-child separation: implications for child allergies and total IgE in China.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Can transcranial Doppler improve risk stratification in pediatric moyamoya?Pediatric research · 2026Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effects of parent-child separation (PCS) are a hot topic in pediatrics, but studies involving the "double hit" of PCS across generations are scarce.
methodsWithin 2279 parent-offspring dyads, the PCS was defined as separated from parents for > 6 months/year early in life, and the intergenerational continuity of PCS means the two generations both experienced PCS, whereas discontinuity refers to just one generation exposed only. Clinical diagnoses or ISAAC-based allergies were reported by caregivers. Capillary blood was collected from children to assess total immunoglobulin E (tIgE).
resultsAmong 2279 parent-offspring dyads, 477 (20.9%) experienced intergenerational continuity of PCS, and 1028 (42.9%) discontinuity. Allergies occurred in 38.0% of the preschoolers. Both intergenerational continuity and children-only exposure were associated with allergies (all P < 0.05). Intergenerational continuity of PCS, in particular, was associated with the highest risk of allergies (OR = 2.12, 95% CI: 1.52-2.95) and the highest tIgE levels (β = 134.18, 95% CI: 8.11-260.25), compared with children without intergenerational PCS. Notably, paternal transmission appears to show a comparatively more substantial association than maternal transmission.
conclusionThe cumulative associations of PCS across generations with allergies and tIgE are consistent with the need to address the intergenerational cycle of disadvantage. IMPACT: Parent-child separation was associated with allergies. Parent-child separation may show cumulative patterns across generations, especially, intergenerational continuity of parent-child separation was associated with the highest risk of allergies and the highest levels of total immunoglobulin E. The association of paternal transmission appeared to be stronger than maternal. The clinicians may consider prioritizing allergy screening for children with the experience of intergenerational continuity of parent-child separation. The findings highlight the need to break the intergenerational cycle of disadvantage.
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Registered trials
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