ArticleScientific reports2026
Physiological characterization of pressure-strain loops indices as non-invasive surrogates for ventriculo-arterial coupling: a proof-of-concept study.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Oral mucosal microbiome alterations in recurrent aphthous stomatitis: a systematic review of 16 S rRNA gene sequencing studies.Molecular biology reports · 2026Pooled it
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Authors and funding
5 authors.
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Abstract
Pressure-strain loop (PSL) analysis integrates myocardial deformation with estimated left ventricular pressure and may provide a non-invasive approach for assessing ventriculo-arterial coupling. However, its physiological behavior under controlled hemodynamic stress has not been systematically evaluated in humans. In this prospective physiologic study, healthy volunteers underwent standardized hemodynamic maneuvers. One cohort performed semi-supine exercise (contractility-dominant), while a second cohort underwent isometric handgrip followed by modified passive leg raising (afterload- and preload-modulating maneuvers). Left-ventricular PSL indices were derived from speckle-tracking echocardiography combined with brachial pressure calibration. Five pre-specified PSL indices reflecting afterload (PSL-derived arterial elastance (EaPSL), end-systolic pressure), contractility (systolic strain rate, peak systolic strain), and myocardial work (global work index) were defined as co-primary endpoints. Within-subject changes were analyzed using paired tests with Holm-Bonferroni correction. Exercise produced large increases in contractility-sensitive indices (Cohen's dz 0.88-1.29, all adjusted p < 0.001), while pressure indices rose selectively with handgrip and modified passive leg raising (Cohen's dz 0.77-1.21, adjusted p ≤ 0.001). These findings demonstrate that PSL analysis detects physiologically meaningful hemodynamic responses in humans and yields non-invasive indices whose directional behavior is consistent with established ventriculo-arterial coupling physiology.
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