Evidence map›Paper›PMID 42062449›Full record

ArticleScientific reports2026

The C16orf87 protein is a subunit of the MIER corepressor complex controlling embryonic development and cell migration.

Tanel Punga, Mårten Larsson, Endrina Mujica, Fabio Rabelo Melo, Christoph Metzendorf, Hanqing Zhang, Dandan Wang, Marcel den Hoed, Leif Andersson, Débora Parrine

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tanel Punga *Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden. tanel.punga@imbim.uu.se.
Mårten Larsson *Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Endrina MujicaThe Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Fabio Rabelo MeloDepartment of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Christoph MetzendorfThe Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Hanqing ZhangThe Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Dandan WangDepartment of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Marcel den HoedThe Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Leif AnderssonDepartment of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Débora ParrineDepartment of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden. debora.parrine@nbis.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Histone modifications by histone deacetylases (HDACs) are essential for controlling chromatin structure and regulating gene expression. Functionally, HDACs act as enzymatic subunits within diverse multisubunit corepressor complexes, thereby targeting distinct sets of genes. Here, we identify C16orf87 as a previously uncharacterized functional subunit of the MIER corepressor complex that mediates HDAC1 and MIER1 protein interactions. Homozygous knockout of C16orf87 alters chromatin accessibility and reduces cell migration in human cells, and impairs embryonic development of zebrafish. Based on these findings, we propose renaming C16orf87 as HDAC Interacting Protein (HDIP) to reflect its newly revealed function.

Indexed as

ChromatinChromatin Assembly and DisassemblyChromosomes, Human, Pair 16DNA-Binding ProteinsEmbryonic DevelopmentGene Expression Regulation, DevelopmentalHistone Deacetylase 1Transcription FactorsAnimalsCell Line, TumorCell MovementGene Knockout TechniquesGenetic LociHumansMiceOpen Reading FramesChromatinDNA-Binding ProteinsHDAC1 protein, humanHistone Deacetylase 1MIER1 protein, humanProtein SubunitsTranscription FactorsC16orf87ChromatinEmbryonic developmentHDAC1MIER1Migration

Identifiers

PMID42062449
PMCPMC13133221

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.