Evidence map›Paper›PMID 42062444›Full record

ArticleScientific reports2026

Impact of vitamin D deficiency on 6-month culture conversion in nontuberculous mycobacterial pulmonary disease.

Tae-Ok Kim, Nakwon Kwak, Doosoo Jeon, Byung Woo Jhun, Kyung-Wook Jo, Young Ae Kang, Hyung-Jun Kim, Hyeontaek Hwang, Joong-Yub Kim, Young Ran Kim and 8 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Tae-Ok KimDepartment of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, 42 Jebongro, Donggu, Gwangju, 61469, South Korea.
Nakwon KwakDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Doosoo JeonDepartment of Internal Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, South Korea.
Byung Woo JhunDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Kyung-Wook JoDivision of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Young Ae KangDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Hyung-Jun KimDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Hyeontaek HwangDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Joong-Yub KimDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Young Ran KimDivision of Clinical Research, International Tuberculosis Research Centre, Seoul, South Korea.
Jae Ho LeeDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Jeongha MokDepartment of Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine, Busan, South Korea.
Youngmok ParkDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Tae Sun ShimDivision of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Hojoon SohnDepartment of Preventive Medicine, College of Medicine, Seoul National University, Seoul, South Korea.
Jake WhangKorea Mycobacterium Resource Center and Basic Research Section, The Korean Institute of Tuberculosis, Cheongju, South Korea.
Jae-Joon YimDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Yong-Soo KwonDepartment of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, 42 Jebongro, Donggu, Gwangju, 61469, South Korea. yskwon@jnu.ac.kr.

Funding

the Ministry of Health & Welfare, Republic of Korea RS-2021-KH119793
6 · The paper itself

Abstract

Vitamin D modulates antimycobacterial immunity, and its deficiency has been implicated in susceptibility to nontuberculous mycobacterial pulmonary disease (NTM-PD). However, whether baseline vitamin D status influences treatment outcomes remains unclear. We analyzed 485 patients with available baseline serum 25-hydroxyvitamin D [25(OH)D] levels and 6-month culture data from a prospective multicenter cohort (NTM-KOREA) enrolled between April 2022 and August 2025. Vitamin D deficiency was defined as 25(OH)D < 20 ng/mL. The mean age was 64.0 years, 73.2% were female, and 99 (20.4%) had vitamin D deficiency. The overall 6-month culture conversion rate was 44.9%, with no significant difference between deficient and non-deficient groups (42.4% vs. 45.6%; p = 0.651). In multivariable logistic regression, vitamin D deficiency was not associated with culture conversion (adjusted odds ratio [aOR] 1.091; 95% CI 0.662-1.797; p = 0.733), whereas guideline-based treatment showed a strong positive association (aOR 3.781; 95% CI 1.825-7.832; p < 0.001). Multivariable Cox regression confirmed no association between vitamin D deficiency and time to conversion (adjusted hazard ratio 1.031; 95% CI 0.721-1.475; p = 0.868). Baseline vitamin D deficiency was not independently associated with 6-month culture conversion or time to conversion in treated NTM-PD patients.

Indexed as

Lung DiseasesMycobacterium Infections, NontuberculousNontuberculous MycobacteriaVitamin D DeficiencyAgedFemaleHumansMaleMiddle AgedProspective StudiesVitamin D25-hydroxyvitamin DVitamin DCulture conversionDeficiencyNontuberculous mycobacterial pulmonary diseaseVitamin D

Identifiers

PMID42062444
PMCPMC13324339

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.