Evidence map›Paper›PMID 42062294›Full record

ArticleNature communications2026

The G protein-casein kinase 2 module acts as a pivot in plasma membrane-to-nucleus CLAVATA signaling to control shoot apical meristem size.

Liu Liu, Jiahao Zhang, Jingyu Guo, Lijie Han, Chaoheng Gu, Xuehui Yao, Ruiqing Lyu, Min Li, Shaoyun Wang, Chuang Li and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Liu LiuBeijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops, Department of Vegetable Sciences, China Agricultural University, Beijing, China.ORCID http://orcid.org/0009-0004-2050-430X
Jiahao ZhangBeijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops, Department of Vegetable Sciences, China Agricultural University, Beijing, China.
Jingyu GuoBeijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops, Department of Vegetable Sciences, China Agricultural University, Beijing, China.
Lijie HanBeijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops, Department of Vegetable Sciences, China Agricultural University, Beijing, China.
Chaoheng GuBeijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops, Department of Vegetable Sciences, China Agricultural University, Beijing, China.
Xuehui YaoInstitute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, China.
Ruiqing LyuDepartment of Biophysics, School of Basic Medical Sciences, Peking University, Beijing, China.
Min LiBeijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops, Department of Vegetable Sciences, China Agricultural University, Beijing, China.
Shaoyun WangBeijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops, Department of Vegetable Sciences, China Agricultural University, Beijing, China.
Chuang LiBeijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops, Department of Vegetable Sciences, China Agricultural University, Beijing, China.
Yan GengBeijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops, Department of Vegetable Sciences, China Agricultural University, Beijing, China.
Jianyu ZhaoBeijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops, Department of Vegetable Sciences, China Agricultural University, Beijing, China.
Lin BaiDepartment of Biophysics, School of Basic Medical Sciences, Peking University, Beijing, China.ORCID http://orcid.org/0000-0002-7535-7819
Xiaolan ZhangBeijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops, Department of Vegetable Sciences, China Agricultural University, Beijing, China. zhxiaolan@cau.edu.cn.ORCID http://orcid.org/0000-0002-6343-3116
Zhaoyang ZhouBeijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops, Department of Vegetable Sciences, China Agricultural University, Beijing, China. zyzhou@cau.edu.cn.ORCID http://orcid.org/0000-0003-2178-9525

Funding

China Postdoctoral Science Foundation 2024M763585National Natural Science Foundation of China (National Science Foundation of China) 32025033
6 · The paper itself

Abstract

The canonical CLAVATA3 (CLV3)-WUSCHEL (WUS) feedback loop functions in shoot apical meristem (SAM) maintenance that directly determines angiosperm shoot architecture and crop yield. However, how CLV3 signaling is transmitted into the nucleus to inhibit WUS expression remains a long-standing mystery. Here, we found that the Cucumis sativus CLV3 (CsCLV3) promotes the nuclear translocation of the CLV receptor-associated Gα protein CsGPA1. CsGPA1 directly interacts with the nuclear-localized protein kinase Casein Kinase II α subunit (CK2α). CK2α negatively regulates the SAM size in a kinase-dependent manner and CsGPA1 promotes the kinase activity of CsCK2α2. CsGPA1 and CsCK2α2 act in the same pathway to regulate SAM size by inhibiting the expression of WUS. Further, the GPA1-CK2α mediated signaling pathway is conserved in tomato SAM maintenance. Therefore, our results provide important new insights into the nature of the CLV3 signaling pathway that leads to WUS repression in plants.

Indexed as

Casein Kinase IICell MembraneCell NucleusCucumis sativusMeristemPlant ProteinsGene Expression Regulation, PlantPlant ShootsSignal TransductionSolanum lycopersicumCasein Kinase IIPlant Proteins

Identifiers

PMID42062294
PMCPMC13338042

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.