ArticleTranslational psychiatry2026
GluK1 kainate receptors in parvalbumin interneurons modulate cortico-hippocampal network dynamics during social behavior.
Article in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The prefrontal cortex orchestrates complex behaviors by communicating with subcortical structures through synchronized oscillations. Here we show that ablation of GluK1 subunit-containing kainate receptors in parvalbumin interneurons (PV INs) disrupts oscillatory dynamics in the cortico-hippocampal circuits mediating social and cognitive behaviors. In control mice, the hippocampus-medial prefrontal cortex (HC-mPFC) circuit displayed elevated theta and gamma oscillation power as well as enhanced functional coupling during interaction with a familiar mouse. Similar circuit dynamics were not observed during interaction with a novel mouse, consistent with the idea that social recognition involves cortico-hippocampal communication. Mice lacking GluK1 in the PV INs (PV-Grik1
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