Evidence map›Paper›PMID 42062153›Full record

ArticleBritish journal of anaesthesia2026

Revisiting MAC as a static measure of anaesthesia: evidence for dynamic responses under isoflurane in male mice.

Aden Mandel, Jackson Soohoo, Chloe Deitelzweig, Isha Patkar, Dennis Han, Madona Farag, Andrew McKinstry-Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of anaesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Uncoupling immobility and unconsciousness.British journal of anaesthesia · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aden MandelSchool of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA.
Jackson SoohooSchool of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA.
Chloe DeitelzweigSchool of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA.
Isha PatkarSchool of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA.
Dennis HanSchool of Nursing, University of Pennsylvania, Philadelphia, PA, USA.
Madona FaragDepartment of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Andrew McKinstry-WuDepartment of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Center for the Neuroscience of Unconsciousness and Reanimation Research Alliance, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Chronobiology and Sleep Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Electronic address: Andrew.McKinstry@pennmedicine.upenn.edu.

Funding

Personalized Anesthesia: The Role of the Locus Coeruleus in Individual Anesthetic ResponsesR35GM142712 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI MCKINSTRY-WU, ANDREW RICH · 2021 to 2025
$2.2M
NIGMS NIH HHS R35 GM142712
6 · The paper itself

Abstract

backgroundThe presence of a righting reflex is known to vary over time in an individual at the population half-maximal effective anaesthetic concentration (EC

methodsMale mice were exposed to fixed concentrations of isoflurane, and aversive pedal stimulation was repeatedly assessed to determine a population EC

resultsLike a righting reflex, at a population EC

conclusionsSimilar to the righting reflex, responses to an aversive stimulus change stochastically in individuals at population EC

Indexed as

Anesthetics, InhalationIsofluraneReflex, RightingAnimalsDose-Response Relationship, DrugMaleMiceMice, Inbred C57BLPhysical StimulationAnesthetics, InhalationIsofluraneanaesthetic sensitivitybehavioural dynamicsbehavioural state transitionisofluraneMACrighting reflex

Identifiers

PMID42062153
PMCPMC13494181

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.