Evidence map›Paper›PMID 42061985›Full record

ArticleLife science alliance2026

Temporal analysis of two inducible human genes reveals post-transcriptional H3K4me3 deposition.

Komal Paresh Walvekar, Sabarinadh Chilaka

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Komal Paresh WalvekarDivision of Applied Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, India.
Sabarinadh ChilakaDivision of Applied Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, India sabarinadhch@gmail.com sabarinadh@csiriict.in.ORCID 0000-0002-8238-150X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Histone H3 lysine 4 trimethylation (H3K4me3) is an established hallmark of active promoters, yet the temporal hierarchy between its deposition and transcriptional initiation remains incompletely understood. Here, we employ temporal dynamic analysis of inducible human inflammatory genes to demonstrate that H3K4me3 accumulation lags significantly behind transcriptional onset. At the

Indexed as

HistonesAcetylationGene Expression RegulationHistone-Lysine N-MethyltransferaseHumansInterleukin-1betaMethylationMyeloid-Lymphoid Leukemia ProteinNF-kappa BPromoter Regions, GeneticRNA Polymerase IITranscriptional ActivationTranscription, GeneticTumor Necrosis Factor-alphahistone H3 trimethyl Lys4Histone-Lysine N-MethyltransferaseHistonesInterleukin-1betaKMT2A protein, humanMyeloid-Lymphoid Leukemia ProteinNF-kappa BRNA Polymerase IITumor Necrosis Factor-alpha

Identifiers

PMID42061985
PMCPMC13135274

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.