ReviewVirus research2026
HIV envelope pseudotyped virus- an indispensable tool in HIV research.
Review in Virus research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
HIV env-pseudotyped viruses have become invaluable tools in HIV research. These recombinant viral particles are generated by co-transfecting HEK293T cells with an envelope cassette containing a heterologous HIV envelope glycoprotein and an envelope-deficient backbone that lacks one or more essential genes, to facilitate only single round infection. The non-infective, replication-deficient nature of env-pseudotyped viruses allows them to be safely handled in a BSL-2 facility. Because of their ability to express heterogeneously derived HIV envelopes, they serve as versatile tools for investigating co-receptor usage and tropism, screening of novel anti-HIV agents, studying neutralizing antibody responses, identifying novel broadly neutralizing antibodies (bNAbs), and for understanding the infectivity and mechanistic potential of different HIV strains. This review summarizes the current methods of generating HIV env-pseudotyped viruses using diverse packaging systems, and their varied applications, sources and limitations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.