Evidence map›Paper›PMID 42061604›Full record

ArticleToxicology2026

Dysregulation of xenobiotic metabolism and mitochondrial dysfunction exacerbate acetaminophen-induced hepatotoxicity in human antigen R-deficient male mice.

Natalie Eppler, Elizabeth Jones, Forkan Ahamed, Naren Raja, Jephte Y Akakpo, Margitta Lebofsky, Lily He, Ira Vats, Priyanka Ghosh, Yifan Yu and 9 more

Abstract read
In one paragraph

Article in Toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Natalie EpplerDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, KS 66160, USA.
Elizabeth JonesDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, KS 66160, USA.
Forkan AhamedDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, KS 66160, USA.
Naren RajaDepartment of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, MO 64108, USA.
Jephte Y AkakpoDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, KS 66160, USA.
Margitta LebofskyDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, KS 66160, USA.
Lily HeDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, KS 66160, USA.
Ira VatsDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, KS 66160, USA.
Priyanka GhoshDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, KS 66160, USA.
Yifan YuDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, KS 66160, USA.
Kaitlyn ThomasDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, KS 66160, USA.
Colin McCoinDepartments of Cell Biology and Physiology, KU Diabetes Institute, and Kansas Center for Metabolism and Obesity Research, University of Kansas Medical Center, KS 66160, USA.
John ThyfaultDepartments of Cell Biology and Physiology, KU Diabetes Institute, and Kansas Center for Metabolism and Obesity Research, University of Kansas Medical Center, KS 66160, USA.
Xiaoqing WuDepartment of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA.
Liang XuDepartment of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA.
Wei CuiDepartment of Pathology, University of Kansas Medical Center, KS 66160, USA.
Rong WangDepartment of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, MO 64108, USA.
Hartmut JaeschkeDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, KS 66160, USA.
Yuxia ZhangDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, KS 66160, USA. Electronic address: lzhang5@kumc.edu.

Funding

RADx-UP: Improving the Response of Local Urban and Rural Communities to Disparities in Covid-19 TestingUL1TR002366 · NCATS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Mario Castro, JAMES STEVEN LEEDER · 2017 to 2026
$44.3M
Pilot Grants ProgramP30GM118247 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI JAESCHKE, HARTMUT W. · 2016 to 2020
$5.5M
RNA-binding protein HuR in liver pathophysiology and carcinogenesisR01DK119131 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ZHANG, YUXIA · 2019 to 2023
$1.8M
NovaSeq X Plus Sequencing SystemS10OD036343 · OD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SMITH, PETER G · 2024 to 2024
$1.1M
NCATS NIH HHS UL1 TR002366NIDDK NIH HHS R01 DK119131NIGMS NIH HHS P30 GM118247NIH HHS S10 OD036343
6 · The paper itself

Abstract

Acetaminophen (APAP) overdose is a leading cause of acute liver failure worldwide. The RNA-binding protein Human antigen R (HuR) is a multifunctional post-transcriptional regulator that plays a pivotal role in cellular stress responses, including those triggered by APAP toxicity. This study investigated the protective role and mechanisms of HuR in APAP-induced hepatotoxicity in male mice. Hepatocyte-specific HuR-deficient (HuR

Indexed as

AcetaminophenChemical and Drug Induced Liver InjuryELAV-Like Protein 1Mitochondria, LiverXenobioticsAnimalsHepatocytesLiverMaleMiceMice, Inbred C57BLMice, KnockoutAcetaminophenElavl1 protein, mouseELAV-Like Protein 1XenobioticsAcetaminophen hepatotoxicityGene knockoutHuman antigen RMale mouseMitochondrial functionXenobiotic metabolism

Identifiers

PMID42061604
PMCPMC13202677

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.