Evidence map›Paper›PMID 42061598›Full record

ReviewExperimental eye research2026

Cross-linked actin networks (CLANs) and their role in the trabecular meshwork.

Aileen Huang, Joseph M Dalloul, Chenna Kesavulu Sugali, Kamesh Dhamodaran, Jiannong Dai, Anjali Rai, Gillian J McLellan, Weiming Mao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Experimental eye research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aileen HuangDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, United States; Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, United States.
Joseph M DalloulDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, United States; Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, United States.
Chenna Kesavulu SugaliDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, United States; Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, United States.
Kamesh DhamodaranDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, United States; Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, United States.
Jiannong DaiDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, United States; Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, United States.
Anjali RaiDepartment of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States.
Gillian J McLellanDepartment of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States.
Weiming MaoDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, United States; Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, United States; Department of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, United States; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, United States; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, United States. Electronic address: weimmao@iu.edu.

Funding

The role of Wnt signaling in treating glucocorticoid-induced glaucomaR01EY031700 · NEI · INDIANA UNIVERSITY INDIANAPOLIS · PI MAO, WEIMING · 2021 to 2025
$2.5M
Targeting TGFBeta-mediated IOP dysregulation in a large animal model of glaucomaR21EY037150 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI MAO, WEIMING, MCLELLAN, GILLIAN JANE · 2025 to 2025
$439k
Short-Term Training in Ophthalmology Research for Medical StudentsT35EY031282 · NEI · INDIANA UNIVERSITY INDIANAPOLIS · PI Ashay D Bhatwadekar, John Thompson Lind · 2020 to 2026
$354k
NEI NIH HHS R01 EY031700NEI NIH HHS R21 EY037150NEI NIH HHS T35 EY031282
6 · The paper itself

Abstract

Glaucoma is a leading cause of irreversible blindness worldwide, characterized by progressive optic neuropathy commonly associated with elevated intraocular pressure (IOP). The trabecular meshwork (TM) is a critical regulator of aqueous humor outflow, and its biological and biomechanical properties directly influence IOP homeostasis. In glaucomatous eyes and in response to various glaucomatous stimuli, TM cells form cross-linked actin networks (CLANs), a special geodesic actin structure. CLANs alter cytoskeletal dynamics, increase cell stiffness, and impair TM function. This review summarizes past and recent research of CLANs, including their inducers, effects on the TM, and role in glaucoma pathogenesis, as well as suggests some future research directions.

Indexed as

Actin CytoskeletonActinsGlaucomaTrabecular MeshworkAnimalsAqueous HumorHumansIntraocular PressureActinsActin cytoskeletonBiomechanicsCell signalingCross-linked actin networksGlaucomaGlucocorticoidsMechanobiologyTrabecular meshwork

Identifiers

PMID42061598
PMCPMC13277339

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.