Evidence map›Paper›PMID 42061589›Full record

ArticleNeuroImage2026

Age dependence of brain oxygen metabolism in adults assessed by 3D constrained quantitative BOLD MRI.

Kathryn M Jaroszynski, Sina Dindarian, Hyunyeol Lee, John A Detre, Felix W Wehrli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kathryn M JaroszynskiDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA.
Sina DindarianDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Hyunyeol LeeDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; School of Electronic and Electrical Engineering, Kyungpook National University, Republic of Korea.
John A DetreDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Felix W WehrliDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: felix.wehrli@pennmedicine.upenn.edu.

Funding

High Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in HumansP41EB029460 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Ravinder Reddy · 2021 to 2026
$7.6M
Academic Industrial Partnership on Advanced Perfusion MRIR01EB031080 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Yulin V Chang, JOHN A DETRE · 2022 to 2026
$2.7M
Training in Structural, Physiologic and Functional MRIT32EB020087 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI JAMES C GEE, Chamith Sudesh Rajapakse · 2016 to 2026
$2.1M
Simultaneous PET/MR Imaging of Brain Glucose and Oxygen Metabolism to Assess Energy Deficits Related to Alzheimer's Disease and the Response to InterventionR01NS131235 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Keith St. Lawrence, Felix W Wehrli · 2024 to 2026
$1.4M
MRI-Based Regional Assessment of Cerebral Metabolism Via 3D Quantitative BOLDR21EB031364 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI WEHRLI, FELIX W · 2022 to 2023
$447k
3D MRI Method for CMRO2 Mapping of the Brain in DementiaR21AG095658 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Felix W Wehrli · 2026 to 2026
$429k
NIA NIH HHS R21 AG095658NIBIB NIH HHS P41 EB029460NIBIB NIH HHS R01 EB031080NIBIB NIH HHS R21 EB031364NIBIB NIH HHS T32 EB020087NINDS NIH HHS R01 NS131235
6 · The paper itself

Abstract

Global and regional variations in cerebral oxygen metabolism are known to be associated with both healthy aging and the early stages of neurodegeneration. To quantify age effects, a recently developed 3D constrained qBOLD protocol was implemented to determine voxelwise OEF, integrated with ASL-derived CBF measurements to compute CMRO

Indexed as

AgingBrainMagnetic Resonance ImagingOxygenOxygen ConsumptionAdultAgedAged, 80 and overCerebrovascular CirculationFemaleHumansImaging, Three-DimensionalMaleMiddle AgedYoung AdultOxygen3D MRIAgingBlood flowBrain mappingBrain oxygen metabolismOxygenationQuantitative BOLD

Identifiers

PMID42061589
PMCPMC13245583

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.