Evidence map›Paper›PMID 42061466›Full record

ArticleThe Journal of allergy and clinical immunology2026

Maternal and perinatal nutritional programming of lung health and disease in childhood and early adulthood: Research gaps and opportunities-National Heart, Lung, and Blood Institute/National Institutes of Health Workshop Report.

Cindy T McEvoy, N Sabrina Idrose, Shyamali C Dharmage, Dinh S Bui, Shannon J Simpson, Bonnie Patchen, Nicole E Marshall, Rachel S Kelly, Susan V Lynch, Catherine M McDonald and 16 more

Abstract readConference Proceedings
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of allergy and clinical immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Cindy T McEvoyDepartment of Pediatrics, Papé Pediatric Research Institute, Oregon Health & Science University, Portland, Ore. Electronic address: mcevoyc@ohsu.edu.
N Sabrina IdroseAllergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia.
Shyamali C DharmageAllergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia.
Dinh S BuiAllergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia.
Shannon J SimpsonWal-yan Respiratory Research Centre, The Kids Research Institute Australia, Perth, Australia; Curtin School of Allied Health, Curtin University, Perth, Australia.
Bonnie PatchenChanning Division of Network Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, Mass.
Nicole E MarshallDivision of Maternal-Fetal Medicine, Oregon Health & Science University, Portland, Ore.
Rachel S KellyChanning Division of Network Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, Mass.
Susan V LynchDepartment of Medicine, Benioff Center for Microbiome Medicine, University of California San Francisco, San Francisco, Calif; Department of Pediatrics, Benioff Center for Microbiome Medicine, University of California San Francisco, San Francisco, Calif.
Catherine M McDonaldClinical Nutrition, Cystic Fibrosis Clinic, Intermountain Primary Children's Hospital Salt Lake City, Salt Lake City, Utah.
Beena G SoodNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
Charlotte PrattNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
Debbie VitalisNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
Qing LuNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
Kecia N CarrollDepartment of Pediatrics, The Icahn School of Medicine at Mount Sinai, New York, NY; Department of Environmental Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY.
Liesbeth DuijtsDivision of Respiratory Medicine and Allergology, Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Division of Neonatology, Department of Neonatal and Pediatric Intensive Care, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Erick FornoDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, Ind; Pediatric Pulmonary Medicine, Riley Hospital for Children, Indianapolis, Ind.
Carina VenterSection of Allergy and Immunology, University of Colorado, Children's Hospital Colorado, Denver, Colo.
Y S PrakashDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minn; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minn.
Audrey N MillerNationwide Children's Hospital and Ohio State University School of Medicine, Columbus, Ohio.
Dawn L DeMeoChanning Division of Network Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, Mass.
Padmaja SubbaraoDivision of Respiratory Medicine & Translational Medicine, Department of Pediatrics, Hospital for Sick Children, Research Institute, University of Toronto, Toronto, Ontario, Canada.
Rodney D BrittDepartment of Pediatrics, Center for Perinatal Research, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio.
Shaon SenguptaDivision of Neonatology, Department of Pediatrics, University of Pennsylvania Perelman School of Medicine and the Children's Hospital of Philadelphia, Philadelphia, Pa.
Sharon A McGrath-MorrowDivision of Pulmonary and Sleep, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa.
Augusto A LitonjuaDivision of Pediatric Pulmonary Medicine, University of Rochester Medical Center, Rochester, Minn.

Funding

SYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASEST32HL007427 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI DAWN L DEMEO, Edwin K Silverman · 1985 to 2026
$13.6M
Multi-omic approaches to mechanisms of vitamin D, environmental influences, and the microbiome on asthmaUH3OD023268 · OD · BRIGHAM AND WOMEN'S HOSPITAL · PI LITONJUA, AUGUSTO A, WEISS, SCOTT T · 2018 to 2022
$13.5M
Maternal vitamin C supplementation to decrease effects of smoking during pregnancy on infant lung function and health:Follow-up of 2 randomized trials and association with changes in DNA methylationUH3OD023288 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia T McEvoy, ELIOT R SPINDEL · 2018 to 2026
$12.1M
RANDOMIZED CONTROLLED TRIAL: VDAART CONTINUATION STUDY - DCC - LEADR01HL091528 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LITONJUA, AUGUSTO A, WEISS, SCOTT T · 2014 to 2018
$9.1M
Vitamin C to Decrease Effects of Smoking during Pregnancy on Offspring Airway Function, Airway Size, and Epigenetic Correlates: VCSIP cohort follow-up through 10 Years of AgeR01HL162951 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia T McEvoy, Cynthia D Morris · 2023 to 2026
$7.0M
NHLBI NIH HHS R01 HL091528NHLBI NIH HHS R01 HL162951NHLBI NIH HHS T32 HL007427NIH HHS UH3 OD023268NIH HHS UH3 OD023288
6 · The paper itself

Abstract

The National Heart, Lung, and Blood Institute-sponsored workshop, "Maternal and Perinatal Nutritional Programming of Lung Health and Disease in Childhood and Early Adulthood: Research Gaps and Opportunities," was convened (October 24-25, 2024) to explore how nutrition before, during, and after pregnancy influences lung development and respiratory health across the lifespan. The workshop focused on identifying critical knowledge gaps, mechanistic pathways, and intervention opportunities. Presentations spanned maternal dietary patterns, specific nutrient supplementation, gestational weight gain, and the role of maternal obesity in offspring wheeze and asthma. The role of early postnatal nutrition, particularly human milk for preterm infants at risk for bronchopulmonary dysplasia, was emphasized. Emerging areas included circadian rhythms and the maternal and infant microbiome, metabolome, and epigenome in mediating nutrition-related respiratory outcomes. Research needs included randomized trials of dietary interventions, mechanistic studies to elucidate biological pathways, and implementation strategies to integrate nutritional interventions into practice. Vulnerable populations were emphasized, including preterm infants and families experiencing food insecurity. Participants emphasized the need for a coordinated research agenda to inform future interventions that could improve outcomes across generations.

Indexed as

LungLung DiseasesMaternal Nutritional Physiological PhenomenaChildDevelopmental Origins of Health and DiseaseFemaleHumansInfantInfant, NewbornNational Heart, Lung, and Blood Institute (U.S.)PregnancyUnited StatesAsthmabronchopulmonary dysplasiadevelopmental origins of health and diseaseepigeneticslung developmentlung function trajectoriesmetabolomicsmicrobiomeomega-3 fatty acidsperinatal nutritionprenatal nutritionvitamin Cvitamin D

Identifiers

PMID42061466
PMCPMC13284845

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.